The role of IL-22 in intestinal health and disease

被引：320

作者：

Keir, Mary E. ^{[1
]}

Yi, Tangsheng ^{[2
]}

Lu, Timothy T. ^{[3
]}

Ghilardi, Nico ^{[4
]}

机构：

[1] Genentech Inc, Biomarker Discovery, San Francisco, CA USA

[2] Genentech Inc, Dept Immunol, San Francisco, CA USA

[3] Genentech Inc, Early Clin Dev, San Francisco, CA USA

[4] DiCE Mol, San Francisco, CA 94080 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 03期

关键词：

INNATE LYMPHOID-CELLS; VERSUS-HOST-DISEASE; EPITHELIAL-CELLS; COLORECTAL-CANCER; TIGHT JUNCTIONS; MUCUS LAYERS; COLON-CANCER; SERUM-LEVELS; STEM-CELLS; INTERLEUKIN-22;

D O I：

10.1084/jem.20192195

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and cancer.

引用

页数：9

共 102 条

[1] Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage [J].

Aparicio-Domingo, Patricia ;

Romera-Hernandez, Monica ;

Karrich, Julien J. ;

Cornelissen, Ferry ;

Papazian, Natalie ;

Lindenbergh-Kortleve, Dicky J. ;

Butler, James A. ;

Boon, Louis ;

Coles, Mark C. ;

Samsom, Janneke N. ;

Cupedo, Tom .

JOURNAL OF EXPERIMENTAL MEDICINE, 2015, 212 (11) :1783-1791

[2] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[3] Crohn's disease [J].

Baumgart, Daniel C. ;

Sandborn, William J. .

LANCET, 2012, 380 (9853) :1590-1605

[4] The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria [J].

Behnsen, Judith ;

Jellbauer, Stefan ;

Wong, Christina P. ;

Edwards, Robert A. ;

George, Michael D. ;

Ouyang, Wenjun ;

Raffatellu, Manuela .

IMMUNITY, 2014, 40 (02) :262-273

[5] IL-23-producing IL-10Rα-deficient gut macrophages elicit an IL-22-driven proinflammatory epithelial cell response [J].

Bernshtein, Biana ;

Curato, Caterina ;

Ioannou, Marianna ;

Thaiss, Christoph A. ;

Gross-Vered, Mor ;

Kolesnikov, Masha ;

Wang, Qian ;

David, Eyal ;

Chappell-Maor, Louise ;

Harmelin, Alon ;

Elinav, Eran ;

Thakker, Paresh ;

Papayannopoulos, Venizelos ;

Jung, Steffen .

SCIENCE IMMUNOLOGY, 2019, 4 (36)

[6] Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis [J].

Bevins, Charles L. ;

Salzman, Nita H. .

NATURE REVIEWS MICROBIOLOGY, 2011, 9 (05) :356-368

[7] Advances in graft-versus-host disease biology and therapy [J].

Blazar, Bruce R. ;

Murphy, William J. ;

Abedi, Mehrdad .

NATURE REVIEWS IMMUNOLOGY, 2012, 12 (06) :443-458

[8] gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis [J].

Bollrath, Julia ;

Phesse, Toby J. ;

von Burstin, Vivian A. ;

Putoczki, Tracy ;

Bennecke, Moritz ;

Bateman, Trudie ;

Nebelsiek, Tim ;

Lundgren-May, Therese ;

Canli, Oezge ;

Schwitalla, Sarah ;

Matthews, Vance ;

Schmid, Roland M. ;

Kirchner, Thomas ;

Arkan, Melek C. ;

Ernst, Matthias ;

Greten, Florian R. .

CANCER CELL, 2009, 15 (02) :91-102

[9] IL-22+ CD4+ T Cells Are Associated with Therapeutic Trichuris trichiura Infection in an Ulcerative Colitis Patient [J].

Broadhurst, Mara J. ;

Leung, Jacqueline M. ;

Kashyap, Vikram ;

McCune, Joseph M. ;

Mahadevan, Uma ;

McKerrow, James H. ;

Loke, P'ng .

SCIENCE TRANSLATIONAL MEDICINE, 2010, 2 (60)

[10] Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab [J].

Brunner, Patrick M. ;

Pavel, Ana B. ;

Khattri, Saakshi ;

Leonard, Alexandra ;

Malik, Kunal ;

Rose, Sharon ;

On, Shelbi Jim ;

Vekaria, Anjali S. ;

Traidl-Hoffmann, Claudia ;

Singer, Giselle K. ;

Baum, Danielle ;

Gilleaudeau, Patricia ;

Sullivan-Whalen, Mary ;

Fuentes-Duculan, Judilyn ;

Li, Xuan ;

Zheng, Xiuzhong ;

Estrada, Yeriel ;

Garcet, Sandra ;

Wen, Huei-Chi ;

Gonzalez, Juana ;

Coats, Israel ;

Cueto, Inna ;

Neumann, Avidan U. ;

Lebwohl, Mark G. ;

Krueger, James G. ;

Guttman-Yassky, Emma .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019, 143 (01) :142-154

← 1 2 3 4 5 6 7 8 9 10 →