(±)-Preisomide: A new alkaloid featuring a rare naturally occurring tetrahydro-2H-1,2-oxazin skeleton from an endophytic fungus Preussia isomera by using OSMAC strategy

被引：18

作者：

Chen, Hai-Li ^{[2
]}

Zhao, Wen-Ting ^{[2
]}

Liu, Qing-Pei ^{[1
]}

Chen, Heng-Ye ^{[1
]}

Zhao, Wei ^{[3
]}

Yang, Deng-Feng ^{[4
]}

Yang, Xiao-Long ^{[1
,4
]}

机构：

[1] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Peoples R China

[2] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China

[3] China Tobacco Yunnan Ind Co Ltd, Res & Dev Ctr, Kunming 650201, Yunnan, Peoples R China

[4] Guangxi Acad Sci, Beibu Gulf Marine Res Ctr, Guangxi Key Lab Marine Nat Prod & Combinatorial B, Nanning 530007, Peoples R China

来源：

FITOTERAPIA | 2020年 / 141卷

基金：

中国国家自然科学基金;

关键词：

Preussia isomera; Panax notoginseng; Oxazin; Antimicrobial activity; METABOLITES; DERIVATIVES; PRODUCTS;

D O I：

10.1016/j.fitote.2020.104475

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new alkaloid, named (+/-)-preisomide (1), together with five known polyketides (2-6), were isolated from an endophytic fungus Preussia isomera in Panax notoginseng by using one strain-many compounds (OSMAC) strategy. Their structures were identified by extensive spectroscopic experiments and comparison with literature data. Structurally, compound 1 possessed a rare naturally occurring tetrahydro-2H-1,2-oxazin ring. Compound 6 displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium, methicinllin-resistant Staphylococcus aureus and multidrug-resistant Enterococcus faecalis with an MIC value of 25 mu g/mL, as well as moderate antifungal activity against Gibberella saubinetii with an MIC value of 50 mu g/mL.

引用

页数：4

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