Aurora kinases

被引：147
作者：
Bolanos-Garcia, VM [1 ]
机构：
[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 08期
关键词：
Aurora kinases; cell division; kinase inhibitors;
D O I：
10.1016/j.biocel.2005.02.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aurora kinases A (also known as Aurora, Aurora-2, AIK, AIR-1, AIRK1, AYK1, BTAK, Egg, MmIAK1 and STK15), Aurora B (also known as Aurora-1, AIM-1, AIK2, AIR-2, AIRK-2, ARK2, IAL-1 and STK12) and Aurora C (also known as AIK3) participate in several biological processes, including cytokinesis and dysregulated chromosome segregation. These important regulators of mitosis are over-expressed in diverse solid tumors. One member of this family of serine-threonine kinases, human Aurora A, has been proposed as a drugable target in pancreatic cancer. The recent determination of the three-dimensional structure of Aurora A has shown that Aurora kinases exhibit unique conformations around the activation loop region. This property has boosted the search and development of inhibitors of Aurora kinases, which might also function as novel antioncogenic agents. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1572 / 1577
页数：6
相关论文
共 19 条
  • [1] INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow
    Adams, RR
    Wheatley, SP
    Gouldsworthy, AM
    Kandels-Lewis, SE
    Carmena, M
    Smythe, C
    Gerloff, DL
    Earnshaw, WD
    [J]. CURRENT BIOLOGY, 2000, 10 (17) : 1075 - 1078
  • [2] AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol
    Anand, S
    Penrhyn-Lowe, S
    Venkitaraman, AR
    [J]. CANCER CELL, 2003, 3 (01) : 51 - 62
  • [3] Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
    Bayliss, R
    Sardon, T
    Vernos, I
    Conti, E
    [J]. MOLECULAR CELL, 2003, 12 (04) : 851 - 862
  • [4] Evolutionary relationships of Aurora kinases: Implications for model organism studies and the development of anti-cancer drugs
    Brown, JR
    Koretke, KK
    Birkeland, ML
    Sanseau, P
    Patrick, DR
    [J]. BMC EVOLUTIONARY BIOLOGY, 2004, 4 (1)
  • [5] The cellular geography of aurora kinases
    Carmena, M
    Earnshaw, WC
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (11) : 842 - 854
  • [6] APC/Fizzy-Related targets Aurora-A kinase for proteolysis
    Castro, A
    Arlot-Bonnemains, Y
    Vigneron, S
    Labbé, JC
    Prigent, C
    Lorca, T
    [J]. EMBO REPORTS, 2002, 3 (05) : 457 - 462
  • [7] Mutational analysis of the phosphorylation sites of the Aie1 (aurora-C) kinase in vitro
    Chen, SH
    Tang, TK
    [J]. DNA AND CELL BIOLOGY, 2002, 21 (01) : 41 - 46
  • [8] Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle
    Dewar, H
    Tanaka, K
    Nasmyth, K
    Tanaka, TU
    [J]. NATURE, 2004, 428 (6978) : 93 - 97
  • [9] Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1
    Hu, HM
    Chuang, CK
    Lee, MJ
    Tseng, TC
    Tang, TK
    [J]. DNA AND CELL BIOLOGY, 2000, 19 (11) : 679 - 688
  • [10] Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
    Katayama, H
    Sasai, K
    Kawai, H
    Yuan, ZM
    Bondaruk, J
    Suzuki, F
    Fujii, S
    Arlinghaus, RB
    Czerniak, BA
    Sen, S
    [J]. NATURE GENETICS, 2004, 36 (01) : 55 - 62
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