Inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells by lignans isolated from Euonymus alatus leaves and twigs

被引：39

作者：

Jeong, Eun Ju ^{[1
,2
]}

Cho, Jung Hee ^{[3
]}

Sung, Sang Hyun ^{[1
,2
]}

Kim, Sun Yeou ^{[4
]}

Kim, Young Choong ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

[3] Jeollanamdo Dev Inst Tradit Korean Med, Jeonnam 529851, South Korea

[4] Kyung Hee Univ, Grad Sch EW Med Sci, Yongin, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 08期

关键词：

Euonymus alatus; Lignan; Inflammation; Nitric oxide; RAW; 264.7; HEDYOTIS-LAWSONIAE; PHENOLIC COMPOUND; CONSTITUENTS; NEOLIGNANS; ACTIVATION; EXPRESSION; QUERCETIN; MEDIATORS; MAGNOLOL; ETHER;

D O I：

10.1016/j.bmcl.2011.02.102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 80% methanolic extract of Euonymus alatus leaves and twigs afforded three new lignans, (-)-threo-4,9,4',9'- tetrahydroxy-3,7,3',5'-tetramethoxy-8-O-8'-neolignan (1), (-)-threo-4,9,4',9'-tetrahydroxy-3,5,7,3'- tetramethoxy-8-O-8'-neolignan (2), (7R,8R,7'R)-(+)-lyoniresinol (3), together with seventeen known lignans (4-20). The structures of 1-20 were elucidated by extensive 1D and 2D spectroscopic methods including H-1 NMR, C-13 NMR, H-1-H-1 COSY, HMQC, HMBC and NOESY. All the isolated compounds except for dilignans (19 and 20) significantly inhibited nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2283 / 2286

页数：4

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