Toxicity of long-term use of proton pump inhibitors in children

被引：74

作者：

De Bruyne, Pauline ^{[1
]}

Ito, Shinya ^{[2
,3
,4
]}

机构：

[1] Univ Ghent, Dept Paediat & Med Genet, De Pintelaan 185, B-9000 Ghent, Belgium

[2] Hosp Sick Children, Div Clin Pharmacol & Toxicol, Toronto, ON, Canada

[3] Univ Toronto, Dept Paediat, Toronto, ON, Canada

[4] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2018年 / 103卷 / 01期

关键词：

ACUTE INTERSTITIAL NEPHRITIS; GASTROESOPHAGEAL-REFLUX DISEASE; CLOSTRIDIUM-DIFFICILE INFECTION; COMMUNITY-ACQUIRED PNEUMONIA; DRUG-INTERACTION PROFILES; BIRTH-WEIGHT INFANTS; CARE-UNIT PATIENTS; ACID SUPPRESSION; ENTERIC INFECTION; CONTROLLED-TRIAL;

D O I：

10.1136/archdischild-2017-314026

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity profiles of PPIs are not well understood particularly in children, PPIs have been associated with increased risks of gastrointestinal and respiratory tract infection, vitamin B-12 deficiency, hypomagnesaemia, bone fractures, and rebound hyperacidity after discontinuation. Prescribers should take into account that PPI uses pose toxicity risks, which remain to be fully characterised in infants and children.

引用

页码：78 / 82

页数：5

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