Grading acute graft-versus-host disease: Time to reconsider

被引：7

作者：

Goyal, Rakesh K. ^{[1
,2
]}

Goyal, Manu ^{[3
]}

Sankaranarayan, Kumar

机构：

[1] UPMC, Childrens Hosp Pittsburgh, Div Blood & Marrow Transplantat & Cellular Therap, Pittsburgh, PA 15224 USA

[2] Univ Pittsburgh, Pittsburgh, PA USA

[3] Univ Calif Berkeley, Elect Engn & Comp Sci, Berkeley, CA 94720 USA

来源：

PEDIATRIC TRANSPLANTATION | 2015年 / 19卷 / 03期

关键词：

HEMATOPOIETIC-CELL TRANSPLANTATION; MARROW-TRANSPLANTATION; GVHD; THERAPY;

D O I：

10.1111/petr.12433

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Acute graft-versus-host disease (GVHD) is a common and serious complication of allogeneic blood and marrow transplantation. Acute GVHD is commonly graded according to modified Glucksberg criteria. There is considerable within-grade heterogeneity with different patterns of skin, liver, or gut involvement. In this commentary, we provide an analytical review of ambiguities in acute GVHD severity scoring and offer specific proposals meant to generate discussion in the BMT community for adoption, refinement, and where appropriate, validation studies.

引用

页码：252 / 254

页数：3

共 15 条

[1]

Blood and Marrow Transplant Clinical Trials Network, TECHN MAN PROC

[2] Management of Acute Graft-Versus-Host Disease in Children [J].

Carpenter, Paul A. ;

MacMillan, Margaret L. .

PEDIATRIC CLINICS OF NORTH AMERICA, 2010, 57 (01) :273-+

[3] Prognostic factors and outcomes of severe gastrointestinal GVHD after allogeneic hematopoietic cell transplantation [J].

Castilla-Llorente, C. ;

Martin, P. J. ;

McDonald, G. B. ;

Storer, B. E. ;

Appelbaum, F. R. ;

Deeg, H. J. ;

Mielcarek, M. ;

Shulman, H. ;

Storb, R. ;

Nash, R. A. .

BONE MARROW TRANSPLANTATION, 2014, 49 (07) :966-971

[4]

Center for International Blood and Marrow Transplant Research, FORM 2100 R3 0 100 D

[5]

COG Stem Cell Committee Consensus Guidelines for Establishing Organ Stage and Overall Grade of Acute Graft Versus Host Disease (GVHD) Cited in Children's Oncology Group protocol ASCT0431, MICHAEL

[6] CLINICAL MANIFESTATIONS OF GRAFT VERSUS HOST DISEASE IN HUMAN RECIPIENTS OF MARROW FROM HL-A-MATCHED SIBLING DONORS [J].

GLUCKSBERG, H ;

STORB, R ;

FEFER, A ;

BUCKNER, CD ;

NEIMAN, PE ;

CLIFT, RA ;

LERNER, KG ;

THOMAS, ED .

TRANSPLANTATION, 1974, 18 (04) :295-304

[7] Reduced Mortality after Allogeneic Hematopoietic-Cell Transplantation. [J].

Gooley, Ted A. ;

Chien, Jason W. ;

Pergam, Steven A. ;

Hingorani, Sangeeta ;

Sorror, Mohamed L. ;

Boeckh, Michael ;

Martin, Paul J. ;

Sandmaier, Brenda M. ;

Marr, Kieren A. ;

Appelbaum, Frederick R. ;

Storb, Rainer ;

McDonald, George B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (22) :2091-2101

[8]

GOYAL RK, 2015, 2015 TAND B IN PRESS

[9] What predicts high risk acute graft-versus-host disease (GVHD) at onset?: identification of those at highest risk by a novel acute GVHD risk score [J].

MacMillan, Margaret L. ;

DeFor, Todd E. ;

Weisdorf, Daniel J. .

BRITISH JOURNAL OF HAEMATOLOGY, 2012, 157 (06) :732-741

[10] Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: Comparison of grading systems [J].

MacMillan, ML ;

Weisdorf, DJ ;

Wagner, JE ;

DeFor, TE ;

Burns, LJ ;

Ramsay, NKC ;

Davies, SM ;

Blazar, BR .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2002, 8 (07) :387-394

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