Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis

被引:10
作者
Sciacca, Vanessa [1 ]
Eckstein, Jan [2 ]
Koerperich, Hermann [2 ]
Fink, Thomas [1 ]
Bergau, Leonard [1 ]
El Hamriti, Mustapha [1 ]
Imnadze, Guram [1 ]
Guckel, Denise [1 ]
Fox, Henrik [3 ,4 ]
Gercek, Muhammed [5 ]
Farr, Martin [5 ]
Burchert, Wolfgang [2 ]
Sommer, Philipp [1 ]
Sohns, Christian [1 ]
Piran, Misagh [2 ]
机构
[1] Ruhr Univ Bochum, Herz & Diabet Zentrum NRW, Clin Electrophysiol, D-32545 Bad Oeynhausen, Germany
[2] Ruhr Univ Bochum, Inst Radiol Nucl Med & Mol Imaging, Herz & Diabet Zentrum NRW, D-32545 Bad Oeynhausen, Germany
[3] Ruhr Univ Bochum, Herz & Diabet Zentrum NRW, Clin Thorac & Cardiovasc Surg, D-32545 Bad Oeynhausen, Germany
[4] Ruhr Univ Bochum, Heart Failure Dept, Herz & Diabet Zentrum NRW, D-32545 Bad Oeynhausen, Germany
[5] Herz & Diabet Zentrum, Clin Gen & Intervent Cardiol Angiol, D-32545 Bad Oeynhausen, Germany
关键词
amyloidosis; left atrial strain; left atrial function; left atrial strain rate; cardiac imaging; PROGNOSTIC VALUE; SURVIVAL;
D O I
10.3390/jcm11113150
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims: The present study aims to evaluate magnetic-resonance-imaging (MRI)-assessed left atrial strain (LAS) and left atrial strain rate (LASR) as potential parameters for the diagnosis of cardiac amyloidosis (CA), the distinction of clinical subtypes and differentiation from other cardiomyopathies. Methods and results: LAS and LASR were assessed by MRI feature tracking in patients with biopsy-proven CA. LAS and LASR of patients with CA were compared to healthy subjects and patients with hypertrophic cardiomyopathy. LAS and LASR were also analyzed concerning differences between patients with transthyretin (ATTR) and light chain amyloidosis (AL). A total of 44 patients with biopsy-proven CA, 19 patients with hypertrophic cardiomyopathy and 24 healthy subjects were included. In 22 CA patients (50%), histological examination identified ATTR as CA subtype and AL in the remaining patients. No significant difference was observed for reservoir, conduit or booster LAS in patients with AL or ATTR. Reservoir LAS, conduit LAS and booster LAS were significantly reduced in patients with CA and HCM as compared to healthy subjects (p < 0.001). Reservoir LAS and booster LAS were significantly reduced in CA as compared to HCM patients (p < 0.001). A linear correlation was observed between LA global reservoir strain and LA-EF (p < 0.001, r = 0.5), conduit strain and global longitudinal LV strain (p < 0.001, r = 0.5), global booster strain rate and LA-EF (p < 0.001, r = 0.6) and between global booster strain rate and LA area at LVED (p < 0.0001, 0.5). Conclusions: LAS and LASR are severely impaired in patients with CA. The MRI-based assessment of LAS and LASR might allow non-invasive diagnosis and categorization of CA and its distinct differentiation from other hypertrophic phenotypes.
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页数:12
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