p27 destruction: Cks1 pulls the trigger

被引：28

作者：

Bartek, J ^{[1
]}

Lukas, J ^{[1
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, Dept Cell Cycle & Canc, DK-2100 Copenhagen, Denmark

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 04期

关键词：

D O I：

10.1038/35070160

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27(Kip1). This process is essential for DNA replication and is aberrantly enhanced in cancer. Surprisingly, new work indicates that this function of Cks1 is independent of CDKs and links Cks1 with the Skp2 subunit of the SCF ubiquitin ligase.

引用

页码：E95 / E98

页数：4

共 16 条

[1] The murine gene p27Kip1 is haplo-insufficient for tumour suppression [J].

Fero, ML ;

Randel, E ;

Gurley, KE ;

Roberts, JM ;

Kemp, CJ .

NATURE, 1998, 396 (6707) :177-180

[2] The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27 [J].

Ganoth, D ;

Bornstein, G ;

Ko, TK ;

Larsen, B ;

Tyers, M ;

Pagano, M ;

Hershko, A .

NATURE CELL BIOLOGY, 2001, 3 (03) :321-324

[3] Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets [J].

Kaiser, P ;

Moncollin, V ;

Clarke, DJ ;

Watson, MH ;

Bertolaet, BL ;

Reed, SI ;

Bailly, E .

GENES & DEVELOPMENT, 1999, 13 (09) :1190-1202

[4] Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase [J].

Kamura, T ;

Koepp, DM ;

Conrad, MN ;

Skowyra, D ;

Moreland, RJ ;

Iliopoulos, O ;

Lane, WS ;

Kaelin, WG ;

Elledge, SJ ;

Conaway, RC ;

Harper, JW ;

Conway, JW .

SCIENCE, 1999, 284 (5414) :657-661

[5] Proteolysis and the G1-S transition:: the SCF connection [J].

Krek, W .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (01) :36-42

[6] Role of the F-box protein Skp2 in lymphomagenesis [J].

Latres, E ;

Chiarle, R ;

Schulman, BA ;

Pavletich, NP ;

Pellicer, A ;

Inghirami, C ;

Pagano, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) :2515-2520

[7] ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity [J].

Ohta, T ;

Michel, JJ ;

Schottelius, AJ ;

Xiong, Y .

MOLECULAR CELL, 1999, 3 (04) :535-541

[8] The Xenopus Suc1/Cks protein promotes the phosphorylation of G2/M regulators [J].

Patra, D ;

Wang, SX ;

Kumagai, A ;

Dunphy, WG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (52) :36839-36842

[9] Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase-promoting complex at mitosis [J].

Patra, D ;

Dunphy, WG .

GENES & DEVELOPMENT, 1998, 12 (16) :2549-2559

[10] Cell cycle: Reaching for a role for the Cks proteins [J].

Pines, J .

CURRENT BIOLOGY, 1996, 6 (11) :1399-1402

← 1 2 →