TFM-Explorer: mining cis-regulatory regions in genomes

被引：24

作者：

Tonon, Laurie ^{[1
]}

Touzet, Helene ^{[1
,2
]}

Varre, Jean-Stephane ^{[1
,2
]}

机构：

[1] INRIA Lille Nord Europe, F-59650 Villeneuve Dascq, France

[2] Univ Lille 1, CNRS, UMR 8022, LIFL, F-59655 Villeneuve Dascq, France

来源：

NUCLEIC ACIDS RESEARCH | 2010年 / 38卷

关键词：

TRANSCRIPTION; TOOLS;

D O I：

10.1093/nar/gkq473

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA-binding transcription factors (TFs) play a central role in transcription regulation, and computational approaches that help in elucidating complex mechanisms governing this basic biological process are of great use. In this perspective, we present the TFM-Explorer web server that is a toolbox to identify putative TF binding sites within a set of upstream regulatory sequences of genes sharing some regulatory mechanisms. TFM-Explorer finds local regions showing overrepresentation of binding sites. Accepted organisms are human, mouse, rat, chicken and drosophila. The server employs a number of features to help users to analyze their data: visualization of selected binding sites on genomic sequences, and selection of cis-regulatory modules. TFM-Explorer is available at http://bioinfo.lifl.fr/TFM.

引用

页码：W286 / W292

页数：7

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