Early insight into antibody-dependent enhancement after SARS-CoV-2 mRNA vaccination

被引：5

作者：

Hasan, Amal ^{[1
]}

Al-Mulla, Mohammad R. ^{[2
]}

Abubaker, Jehad ^{[3
]}

Al-Mulla, Fahd ^{[4
,5
]}

机构：

[1] Dasman Diabet Inst, Res Div, Dept Immunol & Microbiol, Kuwait, Kuwait

[2] Kuwait Univ, Dept Comp Sci & Engn, Kuwait, Kuwait

[3] Dasman Diabet Inst, Res Div, Dept Biochem & Mol Biol, Kuwait, Kuwait

[4] Dasman Diabet Inst, Dept Genet & Bioinformat, Kuwait, Kuwait

[5] Dasman Diabet Inst, Funct Genom, Res Div, Kuwait, Kuwait

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2021年 / 17卷 / 11期

关键词：

SARS-CoV-2; COVID-19; antibody-dependent enhancement; neutralization; antibodies; vaccine; spike protein; RESPONSES;

D O I：

10.1080/21645515.2021.1969855

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Current vaccines, which induce a B-cell-mediated antibody response against the spike protein of SARS-CoV-2, have markedly reduced infection rates. However, the emergence of new variants as a result of SARS-CoV-2 evolution requires the development of novel vaccines that are T-cell-based and that target mutant-specific spike proteins along with ORF1ab or nucleocapsid protein. This approach is more accommodative in inducing highly neutralizing antibodies, without the risk of antibody-dependent enhancement, as well as memory CD8(+)T-cell immunity.

引用

页码：4121 / 4125

页数：5

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