Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

被引:881
作者
Burdusel, Alexandra-Cristina [1 ]
Gherasim, Oana [2 ,3 ]
Grumezescu, Alexandru Mihai [2 ]
Mogoanta, Laurentiu [4 ]
Ficai, Anton [2 ]
Andronescu, Ecaterina [2 ]
机构
[1] Univ Politehn Bucuresti, Fac Engn Foreign Languages, 313 Splaiul Independentei, Bucharest 060042, Romania
[2] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Sci & Engn Oxide Mat & Nanomat, 1-7 Gheorghe Polizu St, Bucharest 011061, Romania
[3] Natl Inst Lasers Plasma & Radiat Phys, Lasers Dept, 409 Atomistilor St, Magurele 077125, Romania
[4] Univ Med & Pharm Craiova, Res Ctr Microscop Morphol & Immunol, 2 Petru Rares St, Craiova 200349, Romania
关键词
silver nanoparticles; biomedical applications; biological interactions; biofunctional performances; intrinsic anti-inflammatory activity; antimicrobial efficiency; DRUG-DELIVERY SYSTEMS; CENTRAL VENOUS CATHETERS; HYDROXYAPATITE COMPOSITE COATINGS; ENHANCED ANTIMICROBIAL ACTIVITY; TISSUE ENGINEERING APPLICATIONS; WOUND-HEALING APPLICATIONS; GRAM-NEGATIVE BACTERIA; ANTIBACTERIAL ACTIVITY; GREEN SYNTHESIS; IN-VITRO;
D O I
10.3390/nano8090681
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.
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页数:25
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