共 40 条
A novel therapeutic peptide targeting myocardial reperfusion injury
被引:14
作者:

Boisguerin, Prisca
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France
Univ Montpellier, CNRS, DIMNP, F-34095 Montpellier, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Covinhes, Aurelie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, INSERM, CNRS, IGF, F-34094 Montpellier, France
Lab Excellence Ion Channel Sci & Therapeut, F-06560 Valbonne, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Gallot, Laura
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, INSERM, CNRS, IGF, F-34094 Montpellier, France
Lab Excellence Ion Channel Sci & Therapeut, F-06560 Valbonne, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Barrere, Christian
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, INSERM, CNRS, IGF, F-34094 Montpellier, France
Lab Excellence Ion Channel Sci & Therapeut, F-06560 Valbonne, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Vincent, Anne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, INSERM, CNRS, IGF, F-34094 Montpellier, France
Lab Excellence Ion Channel Sci & Therapeut, F-06560 Valbonne, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Busson, Muriel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, INSERM, IRCM, F-34298 Montpellier, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Piot, Christophe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, INSERM, CNRS, IGF, F-34094 Montpellier, France
Lab Excellence Ion Channel Sci & Therapeut, F-06560 Valbonne, France
Clin Millenaire, Dept Cardiol Intervent, F-34000 Montpellier, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Nargeot, Joel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, INSERM, CNRS, IGF, F-34094 Montpellier, France
Lab Excellence Ion Channel Sci & Therapeut, F-06560 Valbonne, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Lebleu, Bernard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, CNRS, DIMNP, F-34095 Montpellier, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France

Barrere-Lemaire, Stephanie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montpellier, INSERM, CNRS, IGF, F-34094 Montpellier, France
Lab Excellence Ion Channel Sci & Therapeut, F-06560 Valbonne, France Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France
机构:
[1] Univ Montpellier, CNRS, CRBM, F-34293 Montpellier, France
[2] Univ Montpellier, CNRS, DIMNP, F-34095 Montpellier, France
[3] Univ Montpellier, INSERM, CNRS, IGF, F-34094 Montpellier, France
[4] Lab Excellence Ion Channel Sci & Therapeut, F-06560 Valbonne, France
[5] Univ Montpellier, INSERM, IRCM, F-34298 Montpellier, France
[6] Clin Millenaire, Dept Cardiol Intervent, F-34000 Montpellier, France
关键词:
Cardioprotection;
Apoptosis;
Reperfusion Injury;
Therapeutic peptide;
DAXX;
SIGNAL-TRANSDUCTION PATHWAY;
CELL-DEATH;
ISCHEMIA/REPERFUSION INJURY;
HYDROGEN-PEROXIDE;
DAXX TRAFFICKING;
INFARCT SIZE;
RAT HEARTS;
PROTEIN;
APOPTOSIS;
STRESS;
D O I:
10.1093/cvr/cvz145
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Aims Regulated cell death is a main contributor of myocardial ischaemia-reperfusion (IR) injury during acute myocardial infarction. In this context, targeting apoptosis could be a potent therapeutical strategy. In a previous study, we showed that DAXX (death-associated protein) was essential for transducing the FAS-dependent apoptotic signal during IR injury. The present study aims at evaluating the cardioprotective effects of a synthetic peptide inhibiting FAS:DAXX interaction. Methods and results An interfering peptide was engineered and then coupled to the Tat cell penetrating peptide (Tat-DAXXp). Its internalization and anti-apoptotic properties were demonstrated in primary cardiomyocytes. Importantly, an intravenous bolus injection of Tat-DAXXp (1mg/kg) 5min before reperfusion in a murine myocardial IR model decreased infarct size by 48% after 24h of reperfusion. In addition, Tat-DAXXp was still efficient after a 30-min delayed administration, and was completely degraded and eliminated within 24h thereby reducing risks of potential side effects. Importantly, Tat-DAXXp reduced mouse early post-infarction mortality by 67%. Mechanistically, cardioprotection was supported by both anti-apoptotic and pro-survival effects, and an improvement of myocardial functional recovery as evidenced in ex vivo experiments. Conclusions Our study demonstrates that a single dose of Tat-DAXXp injected intravenously at the onset of reperfusion leads to a strong cardioprotection in vivo by inhibiting IR injury validating Tat-DAXXp as a promising candidate for therapeutic application.
引用
收藏
页码:633 / 644
页数:12
相关论文
共 40 条
- [1] Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion[J]. LIFE SCIENCES, 2007, 80 (22) : 2076 - 2084Arakawa, Masayuki论文数: 0 引用数: 0 h-index: 0机构: Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Dept Biochem & Cell Biol,Nakahara Ku, Kawasaki, Kanagawa 2118533, JapanYasutake, Masahiro论文数: 0 引用数: 0 h-index: 0机构: Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Dept Biochem & Cell Biol,Nakahara Ku, Kawasaki, Kanagawa 2118533, JapanMiyamoto, Masaaki论文数: 0 引用数: 0 h-index: 0机构: Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Dept Biochem & Cell Biol,Nakahara Ku, Kawasaki, Kanagawa 2118533, JapanTakano, Teruo论文数: 0 引用数: 0 h-index: 0机构: Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Dept Biochem & Cell Biol,Nakahara Ku, Kawasaki, Kanagawa 2118533, JapanAsoh, Sadamitsu论文数: 0 引用数: 0 h-index: 0机构: Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Dept Biochem & Cell Biol,Nakahara Ku, Kawasaki, Kanagawa 2118533, JapanOhta, Shigeo论文数: 0 引用数: 0 h-index: 0机构: Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Dept Biochem & Cell Biol,Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan
- [2] Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways[J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (10) : 2633 - 2639Beere, HM论文数: 0 引用数: 0 h-index: 0机构: St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
- [3] Systemic delivery of BH4 anti-apoptotic peptide using CPPs prevents cardiac ischemia-reperfusion injuries in vivo[J]. JOURNAL OF CONTROLLED RELEASE, 2011, 156 (02) : 146 - 153Boisguerin, Prisca论文数: 0 引用数: 0 h-index: 0机构: Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, France Univ Montpellier 1, CNRS, UMR 5235, F-34095 Montpellier 5, France Charite, Inst Med Immunol, D-10115 Berlin, Germany Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, FranceRedt-Clouet, Christelle论文数: 0 引用数: 0 h-index: 0机构: Univ Montpellier 1, CNRS, UMR 5203, Inst Genom Fonct,INSERM,U661, F-34000 Montpellier, France Univ Montpellier 2, CNRS, UMR 5203, Inst Genom Fonct,INSERM,U661, F-34000 Montpellier, France Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, FranceFranck-Miclo, Alicia论文数: 0 引用数: 0 h-index: 0机构: Univ Montpellier 1, CNRS, UMR 5203, Inst Genom Fonct,INSERM,U661, F-34000 Montpellier, France Univ Montpellier 2, CNRS, UMR 5203, Inst Genom Fonct,INSERM,U661, F-34000 Montpellier, France Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, FranceLicheheb, Sana论文数: 0 引用数: 0 h-index: 0机构: Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, France Univ Montpellier 1, CNRS, UMR 5235, F-34095 Montpellier 5, France Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, FranceNargeot, Joel论文数: 0 引用数: 0 h-index: 0机构: Univ Montpellier 1, CNRS, UMR 5203, Inst Genom Fonct,INSERM,U661, F-34000 Montpellier, France Univ Montpellier 2, CNRS, UMR 5203, Inst Genom Fonct,INSERM,U661, F-34000 Montpellier, France Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, FranceBarrere-Lemaire, Stephanie论文数: 0 引用数: 0 h-index: 0机构: Univ Montpellier 1, CNRS, UMR 5203, Inst Genom Fonct,INSERM,U661, F-34000 Montpellier, France Univ Montpellier 2, CNRS, UMR 5203, Inst Genom Fonct,INSERM,U661, F-34000 Montpellier, France Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, FranceLebleu, Bernard论文数: 0 引用数: 0 h-index: 0机构: Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, France Univ Montpellier 1, CNRS, UMR 5235, F-34095 Montpellier 5, France Univ Montpellier 2, CNRS, UMR 5235, F-34095 Montpellier 5, France
- [4] MYOCARDIAL REPERFUSION, LIMITATION OF INFARCT SIZE, REDUCTION OF LEFT-VENTRICULAR DYSFUNCTION, AND IMPROVED SURVIVAL - SHOULD THE PARADIGM BE EXPANDED[J]. CIRCULATION, 1989, 79 (02) : 441 - 444BRAUNWALD, E论文数: 0 引用数: 0 h-index: 0机构: HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA
- [5] Activation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx[J]. SCIENCE, 1998, 281 (5384) : 1860 - 1863Chang, HY论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Fac Dent, Dept Biomat Sci, Bunkyo Ku, Tokyo 1138549, JapanNishitoh, H论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Fac Dent, Dept Biomat Sci, Bunkyo Ku, Tokyo 1138549, JapanYang, XL论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Fac Dent, Dept Biomat Sci, Bunkyo Ku, Tokyo 1138549, JapanIchijo, H论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Fac Dent, Dept Biomat Sci, Bunkyo Ku, Tokyo 1138549, JapanBaltimore, D论文数: 0 引用数: 0 h-index: 0机构: Tokyo Med & Dent Univ, Fac Dent, Dept Biomat Sci, Bunkyo Ku, Tokyo 1138549, Japan
- [6] Daxx silencing sensitizes cells to multiple apoptotic pathways[J]. MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (20) : 7108 - 7121Chen, LY论文数: 0 引用数: 0 h-index: 0机构: Univ Med & Dent New Jersey, Dept Pharmacol, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey, Dept Pharmacol, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USAChen, JD论文数: 0 引用数: 0 h-index: 0机构: Univ Med & Dent New Jersey, Dept Pharmacol, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey, Dept Pharmacol, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA
- [7] TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2013, 377 (1-2) : 35 - 44Chen, Zhiyu论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R ChinaShen, Xiaolu论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R ChinaShen, Fengyan论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R ChinaZhong, Wei论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R ChinaWu, Hai论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R ChinaLiu, Sha论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R ChinaLai, Jiang论文数: 0 引用数: 0 h-index: 0机构: Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R China Shanghai Jiao Tong Univ, Xinhua Hosp, Div Anesthesia & Crit Care Med, Sch Med, Shanghai 200092, Peoples R China
- [8] Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion[J]. BASIC RESEARCH IN CARDIOLOGY, 2011, 106 (03) : 397 - 407Choudhury, Sangita论文数: 0 引用数: 0 h-index: 0机构: Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA USA Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USABae, Soochan论文数: 0 引用数: 0 h-index: 0机构: Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA USA Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USAKe, Qingen论文数: 0 引用数: 0 h-index: 0机构: Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA USA Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USALee, Ji Yoo论文数: 0 引用数: 0 h-index: 0机构: Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA USA Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USAKim, Jacob论文数: 0 引用数: 0 h-index: 0机构: Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA USA Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USAKang, Peter M.论文数: 0 引用数: 0 h-index: 0机构: Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA Chonbuk Natl Univ, Dept BIN Fus Technol, Jeonju, South Korea Harvard Univ, Sch Med, Boston, MA USA Beth Israel Deaconess Med Ctr, Cardiovasc Inst, Boston, MA 02215 USA
- [9] Cyclosporine before PCI in Patients with Acute Myocardial Infarction[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (11) : 1021 - 1031Cung, T. -T.论文数: 0 引用数: 0 h-index: 0机构: Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, France论文数: 引用数: h-index:机构:Cayla, G.论文数: 0 引用数: 0 h-index: 0机构: CHU Nimes, Nimes, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceRioufol, G.论文数: 0 引用数: 0 h-index: 0机构: Hop Cardiovasc & Pneumol Louis Pradel, Lyon, France Univ Lyon 1, F-69365 Lyon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceGarcia-Dorado, D.论文数: 0 引用数: 0 h-index: 0机构: Hosp Univ Vall dHebron, Barcelona, Spain Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceAngoulvant, D.论文数: 0 引用数: 0 h-index: 0机构: CHU Tours, Tours, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceBonnefoy-Cudraz, E.论文数: 0 引用数: 0 h-index: 0机构: Hop Cardiovasc & Pneumol Louis Pradel, Lyon, France Univ Lyon 1, F-69365 Lyon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceGuérin, P.论文数: 0 引用数: 0 h-index: 0机构: Hop Guillaume & Rene Laennec, Nantes, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceElbaz, M.论文数: 0 引用数: 0 h-index: 0机构: CHU Rangueil, F-31054 Toulouse, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceDelarche, N.论文数: 0 引用数: 0 h-index: 0机构: Ctr Hosp Pau, Pau, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceCoste, P.论文数: 0 引用数: 0 h-index: 0机构: Hop Haut Leveque, Bordeaux, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceVanzetto, G.论文数: 0 引用数: 0 h-index: 0机构: CHU Grenoble, Hop A Michallon, F-38043 Grenoble, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceMetge, M.论文数: 0 引用数: 0 h-index: 0机构: Hop Henri Duffau, Avignon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceAupetit, J. -F.论文数: 0 引用数: 0 h-index: 0机构: Ctr Hosp St Joseph & St Luc, Lyon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceJouve, B.论文数: 0 引用数: 0 h-index: 0机构: Ctr Hosp Pays Aix, Aix En Provence, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceMotreff, P.论文数: 0 引用数: 0 h-index: 0机构: Hop Gabriel Montpied, Clermont Ferrand, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceTron, C.论文数: 0 引用数: 0 h-index: 0机构: Hop Charles Nicolle, Rouen, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceLabeque, J. -N.论文数: 0 引用数: 0 h-index: 0机构: Clin Fourcade, Bayonne, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceSteg, P. G.论文数: 0 引用数: 0 h-index: 0机构: Hop Bichat Claude Bernard, AP HP, F-75877 Paris, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceCottin, Y.论文数: 0 引用数: 0 h-index: 0机构: Hop Bocage, Dijon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceRange, G.论文数: 0 引用数: 0 h-index: 0机构: Ctr Hosp Gen, Chartres, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceClerc, J.论文数: 0 引用数: 0 h-index: 0机构: Ctr Hosp Compiegne, Compiegne, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceClaeys, M. J.论文数: 0 引用数: 0 h-index: 0机构: Univ Antwerp Hosp, Edegem, Belgium Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceCoussement, P.论文数: 0 引用数: 0 h-index: 0机构: Algemeen Ziekenhuis St Jan, Brugge, Belgium Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FrancePrunier, F.论文数: 0 引用数: 0 h-index: 0机构: CHU Angers, Angers, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceMoulin, F.论文数: 0 引用数: 0 h-index: 0机构: CHU Nancy Brabois, Vandoeuvre Les Nancy, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceRoth, O.论文数: 0 引用数: 0 h-index: 0机构: CHU Mulhouse, Mulhouse, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceBelle, L.论文数: 0 引用数: 0 h-index: 0机构: Ctr Hosp Annecy, Annecy, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceDubois, P.论文数: 0 引用数: 0 h-index: 0机构: CHU Charleroi, Charleroi, Belgium Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceBarragan, P.论文数: 0 引用数: 0 h-index: 0机构: Polyclin Fleurs, Ollioules, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceGilard, M.论文数: 0 引用数: 0 h-index: 0机构: Hop La Cavale Blanche, Brest, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FrancePiot, C.论文数: 0 引用数: 0 h-index: 0机构: Clin Millenaire, Montpellier, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceColin, P.论文数: 0 引用数: 0 h-index: 0机构: Clin Esquirol, Agen, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceDe Poli, F.论文数: 0 引用数: 0 h-index: 0机构: Clin Esquirol, Agen, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceMorice, M. -C.论文数: 0 引用数: 0 h-index: 0机构: Inst Jacques Cartier, Massy, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceIder, O.论文数: 0 引用数: 0 h-index: 0机构: Clin Diaconat, Mulhouse, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceDubois-Rande, J. -L.论文数: 0 引用数: 0 h-index: 0机构: Ctr Hosp Henri Mondor, Creteil, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceUnterseeh, T.论文数: 0 引用数: 0 h-index: 0机构: Hop Claude Galien, Quincy Sous Senat, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceLe Breton, H.论文数: 0 引用数: 0 h-index: 0机构: Hop Pontchaillou, Rennes, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceBeard, T.论文数: 0 引用数: 0 h-index: 0机构: Clin Ormeau, Tarbes, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceBlanchard, D.论文数: 0 引用数: 0 h-index: 0机构: Clin St Gatien, Tours, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceGrollier, G.论文数: 0 引用数: 0 h-index: 0机构: Hop Cote Nacre, Caen, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceMalquarti, V.论文数: 0 引用数: 0 h-index: 0机构: Clin Sauvegarde, Lyon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceStaat, P.论文数: 0 引用数: 0 h-index: 0机构: Clin Tonkin, Lyon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceSudre, A.论文数: 0 引用数: 0 h-index: 0机构: Hop Cardiol Calmette, Lille, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceElmer, E.论文数: 0 引用数: 0 h-index: 0机构: Lund Univ, Dept Clin Sci, Lund, Sweden Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceHansson, M. J.论文数: 0 引用数: 0 h-index: 0机构: Lund Univ, Dept Clin Sci, Lund, Sweden Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceBergerot, C.论文数: 0 引用数: 0 h-index: 0机构: Hop Cardiovasc & Pneumol Louis Pradel, Lyon, France Univ Lyon 1, F-69365 Lyon, France Clin Invest Ctr & Explorat Fonct Cardiovasc, Lyon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceBoussaha, I.论文数: 0 引用数: 0 h-index: 0机构: Hop Cardiovasc & Pneumol Louis Pradel, Lyon, France Univ Lyon 1, F-69365 Lyon, France Clin Invest Ctr & Explorat Fonct Cardiovasc, Lyon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, FranceJossan, C.论文数: 0 引用数: 0 h-index: 0机构: Hop Cardiovasc & Pneumol Louis Pradel, Lyon, France Univ Lyon 1, F-69365 Lyon, France Clin Invest Ctr & Explorat Fonct Cardiovasc, Lyon, France Ctr Hosp Univ CHU Arnaud de Villeneuve, Montpellier, France
- [10] Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2004, 96 (03) : 397 - 401Genth-Zotz, S论文数: 0 引用数: 0 h-index: 0机构: Johannes Gutenberg Univ Mainz, Dept Med 2, D-55101 Mainz, GermanyBolger, AP论文数: 0 引用数: 0 h-index: 0机构: Johannes Gutenberg Univ Mainz, Dept Med 2, D-55101 Mainz, GermanyKalra, PR论文数: 0 引用数: 0 h-index: 0机构: Johannes Gutenberg Univ Mainz, Dept Med 2, D-55101 Mainz, Germanyvon Haehling, S论文数: 0 引用数: 0 h-index: 0机构: Johannes Gutenberg Univ Mainz, Dept Med 2, D-55101 Mainz, GermanyDoehner, W论文数: 0 引用数: 0 h-index: 0机构: Johannes Gutenberg Univ Mainz, Dept Med 2, D-55101 Mainz, GermanyCoats, AJS论文数: 0 引用数: 0 h-index: 0机构: Johannes Gutenberg Univ Mainz, Dept Med 2, D-55101 Mainz, GermanyVolk, HD论文数: 0 引用数: 0 h-index: 0机构: Johannes Gutenberg Univ Mainz, Dept Med 2, D-55101 Mainz, GermanyAnker, SD论文数: 0 引用数: 0 h-index: 0机构: Johannes Gutenberg Univ Mainz, Dept Med 2, D-55101 Mainz, Germany