Myeloid derived suppressor cells and autoimmunity

被引：62
作者：
Boros, Peter [1 ]
Ochando, Jordi [2 ]
Zeher, Margit [3 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Surg, Recanati Miller Transplant Inst, New York, NY 10129 USA
[2] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10129 USA
[3] Univ Debrecen, Div Clin Immunol, Fac Med, H-4032 Debrecen, Hungary
来源：
HUMAN IMMUNOLOGY | 2016年 / 77卷 / 08期
关键词：
Myeloid derived suppressor cells; Type; 1; diabetes; Rheumatoid arthritis; SLE; Inflammatory bowel disease; REGULATORY T-CELLS; CENTRAL-NERVOUS-SYSTEM; RHEUMATOID-ARTHRITIS; ACTIVATED MONOCYTES; PERIPHERAL-BLOOD; SYNOVIAL-FLUID; MICE; DISEASE; MOUSE; DIFFERENTIATION;
D O I：
10.1016/j.humimm.2016.05.024
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Myeloid-derived suppressor cells are a heterogeneous group of immature myeloid cells with immunoregulatory function. When activated and expanded, these cells can suppress T cell functions via cell-to cell interactions as well as soluble mediators. Recent studies investigated the involvement of MDSC in autoimmune diseases. Some papers have described beneficial effect of MDSC during the course of autoimmune diseases, and suggest a potential role as a treatment option, while others failed to detect these effects. Their contributions to autoimmune diseases are not fully understood, and many questions and some controversies remain as to the expansion, activation, and inhibitory functions of MDSC. This review aims to summarize current knowledge of MDSC in autoimmune disorders. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：631 / 636
页数：6
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