Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

被引：17
作者：
Zhou, Shuqin [1 ,2 ]
Skaar, Debra J. [2 ]
Jacobson, Pamala A. [2 ]
Huang, R. Stephanie [2 ]
机构：
[1] Tongji Univ, Shanghai Peoples Hosp 10, Dept Emergency & Crit Care Med, Shanghai, Peoples R China
[2] Univ Minnesota, Coll Pharm, Dept Expt & Clin Pharmacol, Minneapolis, MN 55455 USA
来源：
FRONTIERS IN PHARMACOLOGY | 2018年 / 9卷
关键词：
pharmacogenomics; personalized medicine; pharmacogenetics; intensive care unit; adverse drug reaction; IMPLEMENTATION CONSORTIUM GUIDELINES; ADVERSE DRUG-REACTIONS; CATECHOL-O-METHYLTRANSFERASE; GUIDED ANTIPLATELET THERAPY; GENETIC-POLYMORPHISM; IN-VITRO; PLASMA-CONCENTRATIONS; CYP2C19; GENOTYPE; INDUCED MYOPATHY; CANCER-PATIENTS;
D O I：
10.3389/fphar.2018.01436
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.
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页数：15
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