Preparation of Alginate Micro-Gel by High Pressure Water Method

被引：0
|
作者：
Murata, Yoshifumi [1 ]
Suzuki, Yasuyuki [1 ]
Isobe, Takashi [1 ]
Kofuji, Kyoko [1 ]
Kawashima, Susumu [1 ]
机构：
[1] Hokuriku Univ, Fac Pharmaceut Sci, Kanazawa, Ishikawa 9201181, Japan
来源：
KOBUNSHI RONBUNSHU | 2010年 / 67卷 / 09期
关键词：
Alginate Micro-Gel; High Pressure Water; Hydrocortisone; Dissolution Profile; BEADS;
D O I：
10.1295/koron.67.549
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Alginate micro-gel (AMG) containing a model compound, hydrocortisone (HC), was prepared by high pressure water method. The release profile of HC from AMG was then investigated. The mean particle size of AMG was less than 100 mu m: the size was controllable by the pressure of water. HC incorporated in AMG was immediately dissolved in physiological saline; the dissolution profile was reproducible. These results suggest that AMG is potentially useful to improve the solubility of water-insoluble compounds.
引用
收藏
页码：549 / 552
页数：4
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