A new alternative to the Mannich reaction:: Tandem radical addition-cyclization reaction for asymmetric synthesis of γ-butyrolactones and β-amino acids

被引：84
|
作者：
Miyabe, H [1 ]
Fujii, K [1 ]
Goto, T [1 ]
Naito, T [1 ]
机构：
[1] Kobe Pharmaceut Univ, Kobe, Hyogo 6588558, Japan
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 25期
关键词：
D O I：
10.1021/ol006716g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The radical addition-cyclization reaction of substrates having two different radical accepters such as acrylate and aldoxime ether moieties was studied. This new free radical mediated Mannichtype reaction proceeded smoothly via a tandem C-C bond-forming process. Furthermore, the diastereoselective tandem reaction provides the novel method for asymmetric synthesis of gamma -butyrolactones and beta -amino acid derivatives.
引用
收藏
页码：4071 / 4074
页数：4
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