Monitoring the cytosolic entry of cell-penetrating peptides using a pH-sensitive fluorophore

被引：69
|
作者：
Qian, Ziqing [1 ]
Dougherty, Patrick G. [1 ]
Pei, Dehua [1 ]
机构：
[1] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 11期
基金：
美国国家卫生研究院;
关键词：
HUMAN IMMUNODEFICIENCY VIRUS; ARGININE-RICH PEPTIDES; REAL-TIME ANALYSIS; INTERNALIZATION MECHANISMS; RAPID ACIDIFICATION; DISULFIDE BONDS; UPTAKE KINETICS; CARGO DELIVERY; LYSOSOMES; PROTEIN;
D O I：
10.1039/c4cc09441g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a simple, effective method to assess the cytosolic delivery efficiency and kinetics of cell-penetrating peptides using a pH-sensitive fluorescent probe, naphthofluorescein.
引用
收藏
页码：2162 / 2165
页数：4
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