DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population

被引:6
作者
da Silva, Ronaldo Celerino [1 ,3 ]
Alves da Cruz, Heidi Lacerda [1 ,3 ]
Cavalcanti Brandao, Lucas Andre [3 ,4 ]
Guimaraes, Rafael Lima [1 ,3 ]
Lapa Montenegro, Lilian Maria [2 ]
Schindler, Haiana Charifker [2 ]
Segat, Ludovica [5 ]
Crovella, Sergio [1 ,3 ]
机构
[1] Univ Fed Pernambuco, Dept Genet, Recife, PE, Brazil
[2] CPqAM FIOCRUZ Pernambuco, Aggeu Magalhaes Res Ctr, Dept Immunol, Recife, PE, Brazil
[3] Univ Fed Pernambuco, LIKA, Recife, PE, Brazil
[4] Univ Fed Pernambuco, Dept Pathol, Recife, PE, Brazil
[5] Inst Maternal & Child Hlth, IRCCS Burlo Garofolo, Trieste, Italy
关键词
Tuberculosis; Innate immunity; DEFB1; Genotyping; Polymorphism; SINGLE-NUCLEOTIDE POLYMORPHISMS; HUMAN BETA-DEFENSIN-1; HIV-1; INFECTION; INNATE IMMUNITY; MYCOBACTERIUM-TUBERCULOSIS; BETA-DEFENSINS; ASSOCIATION; EXPRESSION; BINDING; ALTERS;
D O I
10.1016/j.bjm.2015.09.001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
beta-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50). (C) 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda.
引用
收藏
页码:389 / 393
页数:5
相关论文
共 38 条
[1]   A haplotype map of the human genome [J].
Altshuler, D ;
Brooks, LD ;
Chakravarti, A ;
Collins, FS ;
Daly, MJ ;
Donnelly, P ;
Gibbs, RA ;
Belmont, JW ;
Boudreau, A ;
Leal, SM ;
Hardenbol, P ;
Pasternak, S ;
Wheeler, DA ;
Willis, TD ;
Yu, FL ;
Yang, HM ;
Zeng, CQ ;
Gao, Y ;
Hu, HR ;
Hu, WT ;
Li, CH ;
Lin, W ;
Liu, SQ ;
Pan, H ;
Tang, XL ;
Wang, J ;
Wang, W ;
Yu, J ;
Zhang, B ;
Zhang, QR ;
Zhao, HB ;
Zhao, H ;
Zhou, J ;
Gabriel, SB ;
Barry, R ;
Blumenstiel, B ;
Camargo, A ;
Defelice, M ;
Faggart, M ;
Goyette, M ;
Gupta, S ;
Moore, J ;
Nguyen, H ;
Onofrio, RC ;
Parkin, M ;
Roy, J ;
Stahl, E ;
Winchester, E ;
Ziaugra, L ;
Shen, Y .
NATURE, 2005, 437 (7063) :1299-1320
[2]  
[Anonymous], 2012, Global Tuberculosis Report
[3]   Epithelial antimicrobial peptides in host defense against infection [J].
Bals R. .
Respiratory Research, 1 (3)
[4]   Haploview: analysis and visualization of LD and haplotype maps [J].
Barrett, JC ;
Fry, B ;
Maller, J ;
Daly, MJ .
BIOINFORMATICS, 2005, 21 (02) :263-265
[5]   Variations in the Nrampi gene and susceptibility to tuberculosis in West Africans [J].
Bellamy, R ;
Ruwende, C ;
Corrah, T ;
McAdam, KPWJ ;
Whittle, HC ;
Hill, AVS .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (10) :640-644
[6]   Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene [J].
Bellamy, R ;
Ruwende, C ;
Corrah, T ;
McAdam, KPWJ ;
Thursz, M ;
Whittle, HC ;
Hill, AVS .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (03) :721-724
[7]   Mycobacterium tuberculosis, macrophages, and the innate immune response:: does common variation matter? [J].
Berrington, William R. ;
Hawn, Thomas R. .
IMMUNOLOGICAL REVIEWS, 2007, 219 :167-186
[8]   A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children [J].
Braida, L ;
Boniotto, M ;
Pontillo, A ;
Tovo, PA ;
Amoroso, A ;
Crovella, S .
AIDS, 2004, 18 (11) :1598-1600
[9]   Molecular genetics of Mycobacterium tuberculosis pathogenesis [J].
Clark-Curtiss, JE ;
Haydel, SE .
ANNUAL REVIEW OF MICROBIOLOGY, 2003, 57 :517-549
[10]   A rapid screening of ancestry for genetic association studies in an admixed population from Pernambuco, Brazil [J].
Coelho, A. V. C. ;
Moura, R. R. ;
Cavalcanti, C. A. J. ;
Guimaraes, R. L. ;
Sandrin-Garcia, P. ;
Crovella, S. ;
Brandao, L. A. C. .
GENETICS AND MOLECULAR RESEARCH, 2015, 14 (01) :2876-2884