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Induction of apoptosis in HEp-2 cells by infection with herpes simplex virus type 2
被引:40
|作者:
Koyama, AH
[1
]
Akari, H
Adachi, A
Goshima, F
Nishiyama, Y
机构:
[1] Univ Tokushima, Sch Med, Dept Virol, Tokushima 7708503, Japan
[2] Nagoya Univ, Sch Med, Dis Mechanism & Control Res Inst, Virol Lab, Nagoya, Aichi 4668550, Japan
关键词:
D O I:
10.1007/s007050050473
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Although herpes simplex virus type 1 (HSV-I) does not induce apoptosis in infected HEp-2 cells, herpes simplex virus type 2 (HSV-2) did induce apoptosis in a small but significant fraction of the same cells. Apoptosis was not observed in Vero or HeLa cells infected with HSV-2. In addition, HSV-2 infection in the presence of cycloheximide induced extensive apoptosis of HEp-2 or HeLa cells.
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页码:2435 / 2441
页数:7
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