The Immune System as a Therapeutic Target for Alzheimer's Disease

被引:16
作者
Zieneldien, Tarek [1 ]
Kim, Janice [1 ]
Sawmiller, Darrell [2 ]
Cao, Chuanhai [1 ,3 ]
机构
[1] Univ S Florida, Taneja Coll Pharm, Dept Pharmaceut Sci, Tampa, FL 33612 USA
[2] MegaNano BioTech Inc, 3802 Spectrum Blvd Suite 122, Tampa, FL 33612 USA
[3] Univ S Florida, USF Hlth Byrd Alzheimers Inst, Tampa, FL 33613 USA
来源
LIFE-BASEL | 2022年 / 12卷 / 09期
关键词
immunotherapy; peripheral immune system; aging; microglia; Alzheimer's disease; BETA IMMUNIZATION AN1792; BRAIN-BARRIER BREAKDOWN; TRANSGENIC MOUSE MODEL; CEREBRAL AMYLOID-BETA; A-BETA; CEREBROSPINAL-FLUID; APOLIPOPROTEIN-E; DOUBLE-BLIND; INTRAVENOUS IMMUNOGLOBULIN; CLINICAL-TRIALS;
D O I
10.3390/life12091440
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder and is the most common cause of dementia. Furthermore, aging is considered the most critical risk factor for AD. However, despite the vast amount of research and resources allocated to the understanding and development of AD treatments, setbacks have been more prominent than successes. Recent studies have shown that there is an intricate connection between the immune and central nervous systems, which can be imbalanced and thereby mediate neuroinflammation and AD. Thus, this review examines this connection and how it can be altered with AD. Recent developments in active and passive immunotherapy for AD are also discussed as well as suggestions for improving these therapies moving forward.
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页数:22
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