Biology and therapeutic targeting of tumour-associated macrophages

被引：75
作者：
Beltraminelli, Tim [1 ]
De Palma, Michele [1 ]
机构：
[1] Swiss Fed Inst Technol Lausanne EPFL, Sch Life Sci, Swiss Inst Expt Canc Res ISREC, CH-1015 Lausanne, Switzerland
来源：
JOURNAL OF PATHOLOGY | 2020年 / 250卷 / 05期
基金：
欧洲研究理事会;
关键词：
macrophage; monocyte; tumour microenvironment; therapeutic targeting; clinical trial; ENDOTHELIAL GROWTH-FACTOR; PANCREATIC DUCTAL ADENOCARCINOMA; EPITHELIAL OVARIAN-CANCER; DELTA T-CELLS; BREAST-CANCER; EXTRACELLULAR VESICLES; INFILTRATING MACROPHAGES; IMMUNE CELLS; GM-CSF; INFLAMMATORY MICROENVIRONMENT;
D O I：
10.1002/path.5403
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Macrophages sustain tumour progression by facilitating angiogenesis, promoting immunosuppression, and enhancing cancer cell invasion and metastasis. They also modulate tumour response to anti-cancer therapy in pre-clinical models. This knowledge has motivated the development of agents that target tumour-associated macrophages (TAMs), some of which have been investigated in early clinical trials. Here, we provide a comprehensive overview of the biology and therapeutic targeting of TAMs, highlighting opportunities, setbacks, and new challenges that have emerged after a decade of intense translational and clinical research into these multifaceted immune cells. (c) 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
引用
收藏
页码：573 / 592
页数：20
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