Rapid Intracranial Response to Osimertinib in a Patient with Epidermal Growth Factor Receptor T790M-Positive Adenocarcinoma of the Lung

被引：15
|
作者：
Reichegger, Hermann [1 ]
Jochum, Wolfram [2 ]
Forbs, Diana [2 ]
Hader, Claudia [3 ]
Fruh, Martin [1 ]
机构：
[1] Kantonsspital St Gallen, Dept Med Oncol & Hematol, Rorschacherstr 95, CH-9007 St Gallen, Switzerland
[2] Kantonsspital St Gallen, Inst Pathol, St Gallen, Switzerland
[3] Kantonsspital St Gallen, Dept Radiol & Nucl Med, St Gallen, Switzerland
来源：
ONCOLOGY RESEARCH AND TREATMENT | 2016年 / 39卷 / 7-8期
关键词：
AZD9291; Osimertinib; Intracranial; Lung cancer; Response; EGFR mutation; T790M; EGFR-TKI; ACQUIRED-RESISTANCE; CANCER; AZD9291; METASTASES; INHIBITORS; MUTATION;
D O I：
10.1159/000446759
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Osimertinib (AZD9291, Tagrisso) is a potent, irreversible third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Case Report: Our report demonstrates that osimertinib is able to inhibit the growth of a radiotherapy- and surgery-refractory EGFR T790M-positive brain metastasis in a patient with lung adenocarcinoma. Conclusion: These data show that re-biopsy in EGFR-mutated non-small cell lung cancer patients with acquired TKI resistance should be performed. (C) 2016 S. Karger GmbH, Freiburg
引用
收藏
页码：461 / 463
页数：3
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