Inclusion complexation of nimesulide with β-cyclodextrins

被引：13
|
作者：
Vavia, PR [1 ]
Adhage, NA [1 ]
机构：
[1] Univ Mumbai, Dept Chem Technol Autonomous, Div Pharmaceut, Matunga 400019, Mumbai, India
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 04期
关键词：
D O I：
10.1081/DDC-100102206
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nimesulide (NM), a nonsteroidal anti-inflammatory drug (NSAID) has poor aqueous solubility. The present study describes the complexation of NM with beta-cyclodextrin (beta-CD) and its derivative hydroxypropyl beta-cyclodextrin (HP beta-CD). The complexation was studied by phase solubility method, Fourier transformed infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffractometry (XRD). The complexes were prepared by a freeze-drying technique. The in vitro dissolution rate of drug-HP beta-CD complex was faster compared to the drug-beta-CD complex and drug alone.
引用
收藏
页码：543 / 545
页数：3
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