Inclusion complexation of nimesulide with β-cyclodextrins

被引：13
|
作者：
Vavia, PR [1 ]
Adhage, NA [1 ]
机构：
[1] Univ Mumbai, Dept Chem Technol Autonomous, Div Pharmaceut, Matunga 400019, Mumbai, India
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 04期
关键词：
D O I：
10.1081/DDC-100102206
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nimesulide (NM), a nonsteroidal anti-inflammatory drug (NSAID) has poor aqueous solubility. The present study describes the complexation of NM with beta-cyclodextrin (beta-CD) and its derivative hydroxypropyl beta-cyclodextrin (HP beta-CD). The complexation was studied by phase solubility method, Fourier transformed infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffractometry (XRD). The complexes were prepared by a freeze-drying technique. The in vitro dissolution rate of drug-HP beta-CD complex was faster compared to the drug-beta-CD complex and drug alone.
引用
收藏
页码：543 / 545
页数：3
相关论文
共 50 条
  • [1] Inclusion complexation of nimesulide with β-cyclodextrins and its formulation into tablets
    Vavia, PR
    Adhage, NA
    PROCEEDINGS OF THE 9TH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS, 1999, : 475 - 478
  • [2] Inclusion complexation with cyclodextrins
    Klein, CT
    Viernstein, H
    Wolschann, P
    MINERVA BIOTECNOLOGICA, 2000, 12 (04) : 287 - 292
  • [3] Inclusion complexation of glisentide with α-, β- and γ-cyclodextrins
    Zornoza, A
    Martín, C
    Sánchez, M
    Vélaz, I
    Piquer, A
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 169 (02) : 239 - 244
  • [4] Inclusion complexation of artemisinin with α-, β-, and γ-cyclodextrins
    Wong, JW
    Yuen, KH
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2003, 29 (09) : 1035 - 1044
  • [5] Inclusion Complexation Behaviors of Favipiravir into Cyclodextrins
    Kudo, Kanade
    Takata, Riko
    Yamasaki, Kaito
    Osaka, Issey
    Nakajima, Noriyuki
    Hamada, Masahiro
    Koyama, Yasuhito
    CHEMISTRY LETTERS, 2022, 51 (05) : 518 - 521
  • [6] INCLUSION COMPLEXATION OF DOXORUBICIN AND DAUNORUBICIN WITH CYCLODEXTRINS
    BEKERS, O
    BEIJNEN, JH
    OTAGIRI, M
    BULT, A
    UNDERBERG, WJM
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, 8 (8-12) : 671 - 674
  • [7] Inclusion complexation of tetrabutylammonium iodide by cyclodextrins
    Datta, Biswajit
    Roy, Aditi
    Roy, Mahendra Nath
    JOURNAL OF CHEMICAL SCIENCES, 2017, 129 (05) : 579 - 587
  • [8] The driving forces in the inclusion complexation of cyclodextrins
    Liu, L
    Guo, QX
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2002, 42 (1-2) : 1 - 14
  • [9] The Driving Forces in the Inclusion Complexation of Cyclodextrins
    Lei Liu
    Qing-Xiang Guo
    Journal of inclusion phenomena and macrocyclic chemistry, 2002, 42 : 1 - 14
  • [10] Inclusion complexation of tetrabutylammonium iodide by cyclodextrins
    Biswajit Datta
    Aditi Roy
    Mahendra Nath Roy
    Journal of Chemical Sciences, 2017, 129 : 579 - 587
12345