System-specific activity in response to 9-tetrahydrocannabinol: a functional magnetic resonance imaging study in awake male rats

被引：7
作者：
Madularu, Dan [1 ,2 ,3 ]
Yee, Jason R. [3 ]
Kulkarni, Praveen [3 ]
Ferris, Craig F. [3 ]
机构：
[1] McGill Univ, Dept Psychiat, Fac Med, Montreal, PQ, Canada
[2] McGill Univ, Brain Imaging Ctr, Douglas Mental Hlth Univ Inst, 6875 Lasalle Blvd, Montreal, PQ H4H 1R3, Canada
[3] Northeastern Univ, Ctr Translat NeuroImaging, Boston, MA 02115 USA
来源：
EUROPEAN JOURNAL OF NEUROSCIENCE | 2017年 / 46卷 / 12期
基金：
美国国家卫生研究院;
关键词：
BOLD; cannabis; fMRI; marijuana; neuroimaging; THC; CANNABINOID CB1 RECEPTORS; CAPSAICIN-INDUCED PAIN; FEMALE RATS; OPIOID RECEPTORS; FOOD-INTAKE; LEWIS RATS; DELTA(9)-TETRAHYDROCANNABINOL; AMPHETAMINE; BRAIN; EXPOSURE;
D O I：
10.1111/ejn.13754
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The aim of this study was to assess the effects of two doses of (9)-tetrahydrocannabinol (THC, cannabis' main psychoactive agent) and vehicle on blood-oxygen-level dependent (BOLD) activity in drug-naive, awake rats, in an effort to obtain a THC-specific map of activation in clinically-relevant regions and systems. Intraperitoneal injections of low dose of THC resulted in increased positive and negative BOLD signals compared to vehicle and high dose in areas rich in cannabinoid receptor 1, as well as throughout the pain and hippocampal neural systems. These results offer unique maps of activity, or fingerprints', associated with systemic THC administration, allowing for further comparisons with either additional doses or compounds, or between THC administration modalities (i.e. systemic vs. ingested vs. inhaled), which ultimately adds to the translatability assessment of THC-induced BOLD between animal and human studies.
引用
收藏
页码：2893 / 2900
页数：8
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