En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus

被引：11

作者：

Altieri, Stefanie C. ^{[1
]}

Zhao, Tianna ^{[1
]}

Jalabi, Walid ^{[2
]}

Romito-DiGiacomo, Rita R. ^{[2
]}

Maricich, Stephen M. ^{[1
,3
]}

机构：

[1] Univ Pittsburgh, Richard King Mellon Inst Pediat Res, Dept Pediat, Pittsburgh, PA 15224 USA

[2] Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA

[3] UPMC, Childrens Hosp Pittsburgh, Pittsburgh, PA 15224 USA

来源：

DEVELOPMENTAL NEUROBIOLOGY | 2016年 / 76卷 / 11期

基金：

美国安德鲁·梅隆基金会; 美国国家卫生研究院;

关键词：

auditory; brainstem; deafness; ear; hearing; SUPERIOR OLIVARY COMPLEX; AMPLITUDE-MODULATED TONES; ENGRAILED GENES; EXPRESSION PATTERNS; INFERIOR COLLICULUS; PARAOLIVARY NUCLEUS; EPTESICUS-FUSCUS; COCHLEAR NUCLEUS; AUDITORY NUCLEI; GUINEA-PIGS;

D O I：

10.1002/dneu.22388

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ventral nuclei of the lateral lemniscus (VNLL) are part of the central auditory system thought to participate in temporal sound processing. While the timing and location of VNLL neurogenesis have been determined, the genetic factors that regulate VNLL neuron development are unknown. Here, we use genetic fate-mapping techniques to demonstrate that all glycinergic and glycinergic/GABAergic VNLL neurons derive from a cellular lineage that expresses the homeobox transcription factor Engrailed 1 (En1). We also show that En1 deletion does not affect migration or adoption of a neuronal cell fate but does lead to VNLL neuron death during development. Furthermore, En1 deletion blocks expression of the transcription factor FoxP1 in a subset of VNLL neurons. Together, these data identify En1 as a gene important for VNLL neuron development and survival. (c) 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1266-1274, 2016

引用

页码：1266 / 1274

页数：9

共 47 条

[1] En1 directs superior olivary complex neuron positioning, survival, and expression of FoxP1 [J].

Altieri, Stefanie C. ;

Jalabi, Walid ;

Zhao, Tianna ;

Romito-DiGiacomo, Rita R. ;

Maricich, Stephen M. .

DEVELOPMENTAL BIOLOGY, 2015, 408 (01) :99-108

[2] Hoxb1 neural crest preferentially form glia of the PNS [J].

Arenkiel, BR ;

Gaufo, GO ;

Capecchi, MR .

DEVELOPMENTAL DYNAMICS, 2003, 227 (03) :379-386

[3] Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour [J].

Bacon, C. ;

Schneider, M. ;

Le Magueresse, C. ;

Froehlich, H. ;

Sticht, C. ;

Gluch, C. ;

Monyer, H. ;

Rappold, G. A. .

MOLECULAR PSYCHIATRY, 2015, 20 (05) :632-639

[4] Responses of neurons in the ventral nucleus of the lateral lemniscus to sinusoidally amplitude modulated tones [J].

Batra, Ranjan .

JOURNAL OF NEUROPHYSIOLOGY, 2006, 96 (05) :2388-2398

[5] Medial Superior Olivary Neurons Receive Surprisingly Few Excitatory and Inhibitory Inputs with Balanced Strength and Short-Term Dynamics [J].

Couchman, Kiri ;

Grothe, Benedikt ;

Felmy, Felix .

JOURNAL OF NEUROSCIENCE, 2010, 30 (50) :17111-17121

[6]

COVEY E, 1991, J NEUROSCI, V11, P3456

[7]

COVEY E, 1986, J NEUROSCI, V6, P2926

[8] EXPRESSION PATTERNS OF THE HOMEO BOX-CONTAINING GENES EN-1 AND EN-2 AND THE PROTO-ONCOGENE INT-1 DIVERGE DURING MOUSE DEVELOPMENT [J].

DAVIS, CA ;

JOYNER, AL .

GENES & DEVELOPMENT, 1988, 2 (12B) :1736-1744

[9]

DAVIS CA, 1991, DEVELOPMENT, V111, P287

[10]

DisBonito M, 2013, PLOS GENET, V9, DOI DOI 10.1371/J0URNAL.PGEN.1003249

← 1 2 3 4 5 →