Palladium-Catalyzed Aminocarbonylation of Heteroaryl Iodides

被引：6

作者：

Gajanan ^{[1
]}

Rathod, K. ^{[1
]}

Jain, Rahul ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Sect 67, Sas Nagar 160062, Punjab, India

来源：

CHEMISTRYSELECT | 2022年 / 7卷 / 16期

关键词：

Aminocarbonylation; Chloroform; Diaminocarbonylation; Palladium-catalyzed; Quinolines; SUBSTITUTED QUINOLINES; SELECTIVE SYNTHESIS; ARYL HALIDES; CARBONYLATION; CHLOROFORM; DERIVATIVES; DISCOVERY; ACIDS; CO; INHIBITORS;

D O I：

10.1002/slct.202200773

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium-catalyzed aminocarbonylation of heteroaryl iodides is reported in the presence of chloroform as the carbon monoxide surrogate. The substrate scope of the reaction was demonstrated by the synthesis of quinoline-3-carboxamides and other heteroaryl amides in yields up to 90 % under non-inert conditions and microwave irradiation at 80 degrees C in 30 min. This carbonylation method provides efficient access to previously inaccessible biologically important heteroaryl carboxamides.

引用

页数：6

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