From allylic alcohols to aldols via a novel, efficient reaction catalyzed by Ni-complexes

被引：15
作者：
Cuperly, D [1 ]
Crévisy, C [1 ]
Grée, R [1 ]
机构：
[1] Ecole Natl Super Chim Rennes, Lab Synth & Activat Biomol, UMR 6052, CNRS, F-35700 Rennes, France
来源：
SYNLETT | 2004年 / 01期
关键词：
allylic alcohols; double bond isomerization; aldol reaction; nickel hydrides;
D O I：
10.1055/s-2003-43373
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Allylic alcohols react with aldehydes, in an atom economic aldol-type reaction, in the presence of a catalytic amount of (dppe)NiHCl/MgBr2 mixture. This reaction occurs in good to excellent yields with total regiocontrol and very high chemo control under mild conditions. It is compatible with various types of aldehydes including very bulky ones.
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收藏
页码：93 / 96
页数：4
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