Etanercept alleviates psoriasis by reducing the Th17/Treg ratio and promoting M2 polarization of macrophages

被引：21

作者：

Li, Xiaoqing ^{[1
]}

Jiang, Ming ^{[1
]}

Chen, Xia ^{[2
]}

Sun, Weiguo ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Dermatol, 1 Huanghe West Rd, Huaian 223300, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Pathol, Huaian, Jiangsu, Peoples R China

来源：

IMMUNITY INFLAMMATION AND DISEASE | 2022年 / 10卷 / 12期

关键词：

JAK/STAT3 signaling pathway; macrophage; Netanercept; psoriasis; Th17/Treg; PATHOGENESIS; AUTOIMMUNE; INHIBITION; EXPRESSION;

D O I：

10.1002/iid3.734

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: This study aimed to investigate the effect of etanercept in psoriasis and its underlying mechanism. Methods: Female mice were treated with imiquimod (IMQ) to induce psoriasis, and intraperitoneally administered etanercept (0.1-0.4 mg/ml). The RAW264.7 cells were treated with LPS and IFN-gamma to polarize to M1, and were treated with IL-13 and IL-4 to polarize to M2. Results: In our study, Etanercept markedly reduced the psoriasis area and severity index scores, and epidermal thickness of mice induced by IMQ. In addition, etanercept reduced the levels of TNF-alpha and IL-6/12/23, and enhanced the levels of IL-4/10, reduced Th17/Treg ratio and facilitated the polarization of macrophages to M2 in psoriasis model mice. Furthermore, etanercept inhibited the JAK/STAT3 pathway and increased the protein levels of SOCS1 and SOCS3. Conclusions: In conclusion, our findings indicated that etanercept could inhibit the JAK/STAT3 pathway to reduce Th17/Treg ratio and promote M2 polarization, thereby alleviating psoriasis of mice.

引用

页数：10

共 48 条

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