Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect

被引：42

作者：

Kang, Kyoung Ah ^{[1
,2
]}

Zhang, Rui ^{[1
,2
]}

Piao, Mel Jing ^{[1
,2
]}

Ko, Dong Ok ^{[1
,2
]}

Wang, Zhi Hong ^{[1
,2
]}

Kim, Bum Joon ^{[3
,4
]}

Park, Jae Woo ^{[5
]}

Kim, Hee Sun ^{[6
]}

Kim, Dong Hyun ^{[7
]}

Hyun, Jin Won ^{[1
,2
]}

机构：

[1] Jeju Natl Univ, Dept Biochem, Coll Med, Jeju Si 690756, South Korea

[2] Jeju Natl Univ, Appl Radiol Sci Res Inst, Jeju Si 690756, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Microbiol, Seoul 110799, South Korea

[4] Seoul Natl Univ, Coll Med, Inst Canc Res, Seoul 110799, South Korea

[5] Jeju Natl Univ, Dept Nucl & Energy Engn, Jeju Si 690756, South Korea

[6] Ewha Womans Univ, Coll Med, Dept Neurosci, Seoul 110783, South Korea

[7] Kyung Hee Univ, Coll Pharm, Dept Microbial Chem, Seoul 130701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 03期

关键词：

D O I：

10.1016/j.bmc.2007.10.085

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protective properties of irisolidone (a metabolite of kakkalide by intestinal bacteria) against hydrogen peroxide (H2O2) induced cell damage were investigated. Irisolidone was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and the intracellular reactive oxygen species (ROS), thereby preventing lipid peroxidation and DNA damage. Irisolidone inhibited apoptosis in Chinese hamster lung fibroblast (V79-4) cells induced by H2O2 via radical scavenging activity. This was achieved by the activation of the extracellular signal regulated kinase (ERK) and DNA binding activity of activator protein-1 (AP-1) (a downstream transcription factor of ERK) by irisolidone. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1133 / 1141

页数：9

共 35 条

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