The cysteinyl leukotrienes: Where do they come from? What are they? Where are they going?

被引：33

作者：

Austen, K. Frank ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 02期

关键词：

D O I：

10.1038/ni0208-113

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the inflammatory response via receptors on smooth muscle and on bone marrow-derived inflammatory cells. K. Frank Austen describes the work culminating in the identification, biosynthesis and functional characterization of these moieties.

引用

页码：113 / 115

页数：3

共 24 条

[1] Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis [J].

Ago, Hideo ;

Kanaoka, Yoshihide ;

Irikura, Daisuke ;

Lam, Bing K. ;

Shimamura, Tatsuro ;

Austen, K. Frank ;

Miyano, Masashi .

NATURE, 2007, 448 (7153) :609-U12

[2] ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG .2. ENHANCEMENT OF ANAPHYLACTIC RELEASE OF HISTAMINE AND SLOW REACTING SUBSTANCE BY CERTAIN DIBASIC ALIPHATIC ACIDS AND INHIBITION BY MONOBASIC FATTY ACIDS [J].

AUSTEN, KF ;

BROCKLEHURST, WE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1961, 113 (03) :541-&

[3] ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG .3. EFFECT OF CARBON MONOXIDE, CYANIDE, SALICYLALDOXIME, AND IONIC STRENGTH [J].

AUSTEN, KF ;

BROCKLEHURST, WE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1961, 114 (01) :29-&

[4] ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG .1. EFFECT OF PEPTIDASE SUBSTRATES AND INHIBITORS [J].

AUSTEN, KF ;

BROCKLEHURST, WE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1961, 113 (03) :521-&

[5] Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice [J].

Beller, TC ;

Maekawa, A ;

Friend, DS ;

Austen, KF ;

Kanaoka, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (44) :46129-46134

[6] Leukotriene modifiers in pediatric asthma management [J].

Bisgaard, H .

PEDIATRICS, 2001, 107 (02) :381-390

[7] Treatment of asthma with drugs modifying the leukotriene pathway [J].

Drazen, JM ;

Israel, E ;

O'Byrne, PM .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (03) :197-206

[8] T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells:: Profound induction of leukotriene C4 synthase expression by interleukin 4 [J].

Hsieh, FH ;

Lam, BK ;

Penrose, JF ;

Austen, KF ;

Boyce, JA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (01) :123-133

[9]

ISHIZAKA T, 1970, J IMMUNOL, V104, P854

[10] Attenuated zymosan-induced peritoneal vascular permeability and IgE dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase [J].

Kanaoka, Y ;

Maekawa, A ;

Penrose, JF ;

Austen, KF ;

Lam, BK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) :22608-22613

← 1 2 3 →