Mitochondrial lipid peroxidation and antioxidant system in aged rats

被引：2

作者：

Dogru-Abbasoglu, S

Ugurnal, B

Tamer-Toptani, S

Akdeniz, S

Aykaç-Toker, G

Koçak-Toker, N

Uysal, M ^{[1
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34390 Istanbul, Turkey

[2] Istanbul Univ, Istanbul Fac Med, Dept Histol, TR-34390 Istanbul, Turkey

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1998年 / 27卷 / 01期

关键词：

mitochondria; lipid peroxidation; glutathione; superoxide dismutase; glutathione peroxidase; aging; rats; liver; brain;

D O I：

10.1016/S0167-4943(98)00015-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Mitochondria are especially important in cellular senescence since reactive oxygen species (ROS) have been found to be generated constantly as an endogen threat. On the other hand, mitochondrial defence depends mainly on glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GP(x)). In this study, liver and brain mitochondria of 6- and 22-month-old rats were investigated. Liver mitochondrial malondialdehyde (MDA) levels were found increased, whereas mitochondrial GSH was decreased. SOD activity has been observed elevated, whereas GP(x) was unchanged. However, brain mitochondrial MDA, GSH and SOD and GP(x) activites were found unchanged in old rats. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：35 / 40

页数：6

共 50 条

[41] Lipid peroxidation and the antioxidant system of the brain of developing chicken embryo
Surai, PF
Lisenko, SN
Speake, BK
Noble, RC
Sparks, NHC
BRITISH POULTRY SCIENCE, 1998, 39 : S56 - S57
[42] Influence of α-lipoic acid on lipid peroxidation and antioxidant defence system in blood of insulin-resistant rats
Thirunavukkarasu, V
Anuradha, CV
DIABETES OBESITY & METABOLISM, 2004, 6 (03): : 200 - 207
[43] Evaluation of Lipid Peroxidation—Antioxidant Defense System Depending on the Stage of Stress Reaction in Hypertensive ISIAH Rats
L. I. Kolesnikova
L. R. Kolesnikova
M. A. Darenskaya
L. V. Natyaganova
L. A. Grebenkina
L. I. Korytov
S. I. Kolesnikov
Bulletin of Experimental Biology and Medicine, 2019, 166 : 610 - 612
[44] Effects of gestation and lactation on lipid peroxidation and antioxidant system in sheep
Yur, F
Dede, S
Deger, Y
Mert, N
INDIAN VETERINARY JOURNAL, 2003, 80 (10): : 997 - 998
[45] Effect of antioxidant potential of tropical fruit juices on antioxidant enzyme profiles and lipid peroxidation in rats
da Silva Pereira, Ana Carolina
Dionisio, Ana Paula
Wurlitzer, Nedio Jair
Alves, Ricardo Elesbao
de Brito, Edy Souza
Oliveira e Silva, Ana Mara de
Brasil, Isabella Montenegro
Mancini Filho, Jorge
FOOD CHEMISTRY, 2014, 157 : 179 - 185
[46] Effect of antioxidant supplementation on genetic stability and lipid peroxidation in middle-aged men
Gasparovic, J.
Raslova, K.
Barancokova, M.
Kazimirova, A.
Ins, A. Coll
Smolkova, B.
Horska, A.
Wsolova, L.
Dusinska, M.
Volkovova, K.
ATHEROSCLEROSIS SUPPLEMENTS, 2006, 7 (03) : 446 - 446
[47] Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats
Shang, YZ
Ye, JW
Tang, XC
ACTA PHARMACOLOGICA SINICA, 1999, 20 (09): : 824 - 828
[48] Effect of α-tocopherol on lipid peroxidation and total antioxidant status in spontaneously hypertensive rats
Newaz, MA
Nawal, NNA
AMERICAN JOURNAL OF HYPERTENSION, 1998, 11 (12) : 1480 - 1485
[49] MORIN, A FLAVONOID, ON LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN EXPERIMENTAL MYOCARDIAL ISCHEMIC RATS
Al-Numair, Khalid S.
Chandramohan, Govindasamy
Alsaif, Mohammed A.
Veeramani, Chinnadurai
El Newehy, Ahmed S.
AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, 2014, 11 (03) : 14 - 20
[50] Combined effect of alcohol and cigarette smoke on lipid peroxidation and antioxidant status in rats
Bindu, MP
Annamalai, PT
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2004, 41 (01): : 40 - 44

← 1 2 3 4 5 →