Mitochondrial lipid peroxidation and antioxidant system in aged rats

被引：2
|
作者：
Dogru-Abbasoglu, S
Ugurnal, B
Tamer-Toptani, S
Akdeniz, S
Aykaç-Toker, G
Koçak-Toker, N
Uysal, M [1 ]
机构：
[1] Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34390 Istanbul, Turkey
[2] Istanbul Univ, Istanbul Fac Med, Dept Histol, TR-34390 Istanbul, Turkey
来源：
ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1998年 / 27卷 / 01期
关键词：
mitochondria; lipid peroxidation; glutathione; superoxide dismutase; glutathione peroxidase; aging; rats; liver; brain;
D O I：
10.1016/S0167-4943(98)00015-6
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Mitochondria are especially important in cellular senescence since reactive oxygen species (ROS) have been found to be generated constantly as an endogen threat. On the other hand, mitochondrial defence depends mainly on glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GP(x)). In this study, liver and brain mitochondria of 6- and 22-month-old rats were investigated. Liver mitochondrial malondialdehyde (MDA) levels were found increased, whereas mitochondrial GSH was decreased. SOD activity has been observed elevated, whereas GP(x) was unchanged. However, brain mitochondrial MDA, GSH and SOD and GP(x) activites were found unchanged in old rats. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：35 / 40
页数：6
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