Bioactive glass-polymer materials for controlled release of ibuprofen

被引：59
作者：
de Guevara-Fernández, SL [1 ]
Ragel, CV [1 ]
Vallet-Regí, M [1 ]
机构：
[1] Univ Complutense, Dept Quim Inorgan & Bioinorgan, Fac Farm, Madrid 28040, Spain
来源：
BIOMATERIALS | 2003年 / 24卷 / 22期
关键词：
drug release; bioactive glasses; in vitro test; polylactic acid; polymethylmethacrylate;
D O I：
10.1016/S0142-9612(03)00279-5
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The ibuprofen (1B) release from samples composed by SiO2-CaO-P2O5 bioactive glass, poly-L-lactic acid (PLA), and polymethylmethacrylate (PMMA) has been studied. Data showed a fast anti-inflammatory drug release during the first 8 h when these polyphasic materials are soaked in simulated body fluid (SBF). The analysis of the samples before and after different soaking periods in SBF demonstrates the growth of an apatite-like layer on the materials surface. The 113 release rate is related with the growth kinetics of this layer, that is slower when the materials do not contain the biodegradable polymer PLA. On the other hand, different 113 and/or glass contents do not affect the in vitro behavior of these materials. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4037 / 4043
页数：7
相关论文
共 42 条
  • [1] [Anonymous], BIOCERAMICS
  • [2] Bioactivity in glass/PMMA composites used as drug delivery system
    Arcos, D
    Ragel, CV
    Vallet-Regí, M
    [J]. BIOMATERIALS, 2001, 22 (07) : 701 - 708
  • [3] HYDROXYAPATITE REINFORCED POLYETHYLENE - A MECHANICALLY COMPATIBLE IMPLANT MATERIAL FOR BONE-REPLACEMENT
    BONFIELD, W
    GRYNPAS, MD
    TULLY, AE
    BOWMAN, J
    ABRAM, J
    [J]. BIOMATERIALS, 1981, 2 (03) : 185 - 186
  • [4] Three-dimensional degradable porous polymer-ceramic matrices for use in bone repair
    Devin, JE
    Attawia, MA
    Laurencin, CT
    [J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1996, 7 (08) : 661 - 669
  • [5] DUCHEYNE P, 1992, CLIN ORTHOP RELAT R, P102
  • [6] Goodwin CJ, 1997, J BIOMED MATER RES, V34, P47
  • [7] Influence of alpha-Al2O3 morphology and particle size on drug release from ceramic/polymer composites
    Granado, S
    Ragel, V
    Cabanas, V
    SanRoman, J
    ValletRegi, M
    [J]. JOURNAL OF MATERIALS CHEMISTRY, 1997, 7 (08) : 1581 - 1585
  • [8] Hench L.L., 1998, HDB BIOMATERIAL PROP, P355, DOI DOI 10.1007/978-1-4615-5801-9_22
  • [9] BIOCERAMICS - FROM CONCEPT TO CLINIC
    HENCH, LL
    [J]. JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 1991, 74 (07) : 1487 - 1510
  • [10] A new composite made of polyurethane and glass ceramic in a loaded implant model: a biomechanical and histological analysis
    Ignatius, A
    Unterricker, K
    Wenger, K
    Richter, M
    Claes, L
    Lohse, P
    Hirst, H
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1997, 8 (12) : 753 - 756
12345