Synthesis of 3-deazathiamine

被引：28

作者：

Hawksley, D

Griffin, DA

Leeper, FJ

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[2] Zeneca Agrochem, Jealotts Hill Res Stn, Bracknell RG42 6ET, Berks, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 02期

关键词：

D O I：

10.1039/b006962k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient ten-step synthesis of deazathiamine is described. The synthesis starts from commercially available alpha -acetyl-gamma -butyrolactone and proceeds via deamination of the key aminothiophene 6. The Gewald synthesis of thiophenes is shown to give a mixture of isomeric products with the unsymmetric ketone used here and so a modified procedure giving a single isomer is developed.

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页码：144 / 148

页数：5

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