A nonlinear explanation of aging-induced changes in heartbeat dynamics

被引:46
作者
Giuliani, A
Piccirillo, G
Marigliano, V
Colosimo, A
机构
[1] Ist Super Sanita, Comparat Toxicol & Ecotoxicol Lab, I-00161 Rome, Italy
[2] Prima Clin Med Policlin Umberto 1, I-00161 Rome, Italy
[3] Univ Roma La Sapienza, Dipartimento Sci Biochim, I-00185 Rome, Italy
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1998年 / 275卷 / 04期
关键词
recurrence quantification analysis; nonlinear dynamics; heart rate variability; terminal dynamics;
D O I
10.1152/ajpheart.1998.275.4.H1455
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The possibility of computing a cardiac age on the basis of spectral analysis of healthy individual tachograms was confirmed and facilitated by the use of a nonlinear technique: recurrence quantification analysis. The age of 112 subjects was predicted by this technique in terms of a progressive increase in the deterministic character of the heartbeat. This result confirms the "random-walk" character of the heartbeat as predicted by the terminal dynamics paradigm, thus allowing for a simple and comprehensive model of the effect of aging on cardiac dynamics: as age progresses, heart rate dynamics become increasingly predictable (constrained) on a beat-to-beat basis. This implies a basically stochastic nature of heart rate dynamics, probably reflecting the continuous adjustments to an unpredictable internal environment.
引用
收藏
页码:H1455 / H1461
页数:7
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