Genome-wide association studies for common diseases and complex traits

被引：1627

作者：

Hirschhorn, JN

Daly, MJ

机构：

[1] MIT, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02139 USA

[2] Harvard Univ, Broad Inst, Cambridge, MA 02139 USA

[3] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[5] Childrens Hosp, Div Genet, Boston, MA 02115 USA

[6] Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA

[7] Childrens Hosp, Program Genom, Boston, MA 02115 USA

[8] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 02期

关键词：

D O I：

10.1038/nrg1521

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic factors strongly affect susceptibility to common diseases and also influence disease-related quantitative traits. Identifying the relevant genes has been difficult, in part because each causal gene only makes a small contribution to overall heritability. Genetic association studies offer a potentially powerful approach for mapping causal genes with modest effects, but are limited because only a small number of genes can be studied at a time. Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care.

引用

收藏

页码：95 / 108

页数：14

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