Short- and long-term memory are differentialy modulated by hippocampal nerve growth factor and fibroblast growth factor

被引：11
作者：
Walz, R
Roesler, R
Reinke, A
Martins, MR
Quevedo, J [1 ]
Izquierdo, I
机构：
[1] Univ Extremo Sul Catarinense, Lab Neurociencias, BR-88806000 Criciuma, SC, Brazil
[2] Univ Vale Itajai, Dept Med, BR-88302202 Itajai, SC, Brazil
[3] Univ Fed Rio Grande Sul, Inst Ciencias Basicas Saude, Lab Neurofarmacol Preclin, BR-90046900 Porto Alegre, RS, Brazil
[4] Univ Fed Rio Grande Sul, INst Ciencias Basicas Saude, Dept Bioquim, Ctr Memoria, BR-90035003 Porto Alegre, RS, Brazil
来源：
NEUROCHEMICAL RESEARCH | 2005年 / 30卷 / 02期
关键词：
NGF; FGF; memory consolidation; rat;
D O I：
10.1007/s11064-004-2440-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rats were implanted with cannulae in the CA1 area of the dorsal hippocampus and trained in one-trial step-down inhibitory avoidance. Two retention tests were carried out in each animal, one at 1.5 h to measure short-term memory (STM) and another at 24 h to measure long-term memory (LTM). The purpose of the present study was to evaluate the modulation on hippocampal nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) on short- and long-term memory. Immediately after training, animals received 5 mu l of NGF (0.05, 0.5 or 5.0 ng), bFGF (1.25, 12.5 or 125 ng) or saline per side. At the higher dose, NGF blocked STM. In contrast, NGF at dose of 0.5 and 5.0 ng improved LTM. The bFGF infusion at a dose of 125 ng enhanced LTM. However, bFGF did not alter STM. These findings indicate that hippocampal NGF and bFGF modulate STM and LTM in a different manner.
引用
收藏
页码：185 / 190
页数：6
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