Targeting kinases in CML CLL

被引：4

作者：

Gandhi, Varsha ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

BLOOD | 2010年 / 116卷 / 12期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; SPLEEN TYROSINE KINASE; MECHANISMS; INHIBITOR; SYK;

D O I：

10.1182/blood-2010-07-289900

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1999 / 2000

页数：2

共 15 条

[1] Effect of Btk inhibitor PCI-32765 monotherapy on responses in patients with relapsed aggressive NHL: Evidence of antitumor activity from a phase I study [J].

Advani, R. ;

Sharman, J. P. ;

Smith, S. M. ;

Pollyea, D. A. ;

Boyd, T. E. ;

Grant, B. W. ;

Kolibaba, K. S. ;

Buggy, J. J. ;

Hamdy, A. ;

Fowler, N. H. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)

[2] Spleen Tyrosine Kinase Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia [J].

Buchner, Maike ;

Fuchs, Simon ;

Prinz, Gabriele ;

Pfeifer, Dietmar ;

Bartholome, Kilian ;

Burger, Meike ;

Chevalier, Nina ;

Vallat, Laurent ;

Timmer, Jens ;

Gribben, John G. ;

Jumaa, Hassan ;

Veelken, Hendrik ;

Dierks, Christine ;

Zirlik, Katja .

CANCER RESEARCH, 2009, 69 (13) :5424-5432

[3] Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells [J].

Chen, Lisa S. ;

Redkar, Sanjeev ;

Bearss, David ;

Wierda, William G. ;

Gandhi, Varsha .

BLOOD, 2009, 114 (19) :4150-4157

[4] Mechanisms of disease: Chronic lymphocytic leukemia [J].

Chiorazzi, N ;

Rai, KR ;

Ferrarini, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) :804-815

[5] Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia [J].

Friedberg, Jonathan W. ;

Sharman, Jeff ;

Sweetenham, John ;

Johnston, Patrick B. ;

Vose, Julie M. ;

LaCasce, Ann ;

Schaefer-Cutillo, Julia ;

De Vos, Sven ;

Sinha, Rajni ;

Leonard, John P. ;

Cripe, Larry D. ;

Gregory, Stephanie A. ;

Sterba, Michael P. ;

Lowe, Ann M. ;

Levy, Ronald ;

Shipp, Margaret A. .

BLOOD, 2010, 115 (13) :2578-2585

[6]

FURMAN R, 2010, J CLIN ONCOL, V28, pS15

[7] Mcl-1: the 1 in CLL [J].

Gandhi, Varsha ;

Balakrishnan, Kumudha ;

Chen, Lisa S. .

BLOOD, 2008, 112 (09) :3538-3540

[8] Early Events in B Cell Activation [J].

Harwood, Naomi E. ;

Batista, Facundo D. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 28, 2010, 28 :185-210

[9] Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals [J].

Herman, Sarah E. M. ;

Gordon, Amber L. ;

Wagner, Amy J. ;

Heerema, Nyla A. ;

Zhao, Weiqiang ;

Flynn, Joseph M. ;

Jones, Jeffrey ;

Andritsos, Leslie ;

Puri, Kamal D. ;

Lannutti, Brian J. ;

Giese, Neill A. ;

Zhang, Xiaoli ;

Wei, Lai ;

Byrd, John C. ;

Johnson, Amy J. .

BLOOD, 2010, 116 (12) :2078-2088

[10] The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development [J].

Kulathu, Yogesh ;

Hobeika, Elias ;

Turchinovich, Gleb ;

Reth, Michael .

EMBO JOURNAL, 2008, 27 (09) :1333-1344

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