Tumor necrosis factor-alpha stimulates the production of squamous cell carcinoma antigen in normal squamous cells

被引：21
|
作者：
Numa, F [1 ]
Takeda, O [1 ]
Nakata, M [1 ]
Nawata, S [1 ]
Tsunaga, N [1 ]
Hirabayashi, K [1 ]
Suminami, Y [1 ]
Kato, H [1 ]
Hamanaka, S [1 ]
机构：
[1] YAMAGUCHI ROSAI HOSP,DEPT DERMATOL,ONODA,JAPAN
来源：
TUMOR BIOLOGY | 1996年 / 17卷 / 02期
关键词：
squamous cell carcinoma antigen; tumor necrosis factor-alpha; squamous epithelium; normal; keratinocyte;
D O I：
10.1159/000217972
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Squamous cell carcinoma (SCC) antigen, a tumor marker of squamous cell carcinoma, is also increased in several nonmalignant skin lesions, e.g. pemphigus. The aim of the present investigation was to determine if tumor necrosis factor-alpha (TNF-alpha), one of the important environmental factors, stimulated the production of SCC antigen in the normal squamous cells. The exposure of normal human epidermal keratinocytes to TNF-alpha (100 IU/ml) for 72 h greatly increased the SCC antigen production. The stimulatory effect of TNF-alpha (1,000 IU/ml) on the production of SCC antigen was also observed in the normal squamous epithelium tissue. These results would be helpful for understanding the increase of SCC antigen in several nonmalignant skin disorders.
引用
收藏
页码：97 / 101
页数：5
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