Solvent-Free Knoevenagel Condensation over Cobalt Hydroxyapatite

被引：21

作者：

Pillai, Manoharan Karuppiah ^{[1
]}

Singh, Sooboo ^{[1
]}

Jonnalagadda, Sreekanth B. ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem, ZA-4000 Durban, South Africa

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 24期

基金：

新加坡国家研究基金会;

关键词：

Cobalt hydroxyapatite; environment friendly; Knoevenagel condensation; solvent-free condition; SELECTIVE OXIDATION; ALDEHYDES; CATALYSTS; CHLORIDE; MALONONITRILE; FLUORIDE; ALUMINA; MEDIA; PHASE; BASE;

D O I：

10.1080/00397910903531714

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Knoevenagel condensation between various aldehydes (benzaldehyde, 1-naphthaldehyde, p-bromobenzaldehyde and p-methoxybenzaldehyde) and esters (ethylcyanoacetate, ethylacetoacetate and diethylmalonoester) was carried out under solvent free condition in the presence of cobalt hydroxyapatite (CoHAp), as a catalyst. Good to excellent yields (35-96%) were obtained. The catalyst is found to be superior over fluorapatite and several other heterogeneous catalysts. The catalyst can be recycled at least 3 times.

引用

页码：3710 / 3715

页数：6

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