Synthesis and anti-microbial activity of (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxoindolin-3-ylidene) semicarbazide and its derivatives

被引:0
作者
Basavarajaiah, S. M. [1 ]
Mruthyunjayaswamy, B. H. M. [1 ]
机构
[1] Gulbarga Univ, Dept Studies & Res Chem, Gulbarga 585106, India
来源
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2010年 / 49卷 / 08期
关键词
Thiazole; isatin; Schiff base; anti-microbial activity; ANTIBACTERIAL; ANTIFUNGAL; COMPLEXES;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
3-[(2S)-3-Acetyl-5-amino-N-(4-substituted-thiazol-2-yl)2,3-dihydro-1,3,4-oxadiazol-2-yl]-indolin-2-yl acetates, 1-{N-[(2R)-2-(-2-oxoindolin-3-ylidene)-4-oxo-1,3-thiazolidin-3-yl]-3-(4-substituted-thiazol-2yl)ureas, N-(4-substituted-thiazol-2-yl)-[1,3,4]-oxadiazino[6,5]indol-3-amines and (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxo-1-(substituted) methyl)indolin-3-ylidene)semicarbazides have been prepared by making use of (Z)-4-(4-substituted-thiazol-2-yl)-1-(2-oxoindolin-3-ylidene) semicarbazides obtained by the reaction of (4-substituted thiazole-2-yl) semicarbazides and isatin. The structures of the newly synthesized compounds have been confirmed on the basis of analytical, IR, H-1 NMR and mass spectral data. The newly synthesized compounds have been screened for their antimicrobial activities.
引用
收藏
页码:1117 / 1126
页数:10
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