P-(alkyl)-nucleoside 5′-hydrogenphosphonates as depot forms of antiviral nucleotide analogues

被引：9

作者：

Khandazhinskaya, AL ^{[1
]}

Shirokova, EA ^{[1
]}

Karpenko, IL ^{[1
]}

Zakirova, NF ^{[1
]}

Tarussova, NB ^{[1
]}

Krayevsky, AA ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 117984, Russia

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 10-12期

关键词：

D O I：

10.1080/15257770008045461

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

P-(Alkyl)esters of AZT 5'-hydrogenphosphonate were synthesized and their stabilities in the phosphate buffer and human serum were evaluated. The esters bearing residues of primary and secondary alcohols were degraded to give AZT, whereas those containing tertiary alkyl groups yielded, AZT 5'-hydrogenphosphonate. The corresponding derivatives of d2A and d4T showed the same properties.

引用

页码：1795 / 1804

页数：10

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