VEGF: an update on biological and therapeutic aspects

被引：333

作者：

Farrara, N ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Oncol, S San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(00)00153-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that the inhibition of VEGF activity may be beneficial for these conditions.

引用

页码：617 / 624

页数：8

共 108 条

[1] Elevated levels of interleukin-2, soluble interleukin-2 receptor alpha, interleukin-6, soluble interleukin-6 receptor and vascular endothelial growth factor in serum and ascitic fluid of patients with severe ovarian hyperstimulation syndrome [J].

Aboulghar, MA ;

Mansour, RT ;

Serour, GI ;

El Helw, BA ;

Shaarawy, M .

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1999, 87 (01) :81-85

[2] Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis [J].

Adams, RH ;

Wilkinson, GA ;

Weiss, C ;

Diella, F ;

Gale, NW ;

Deutsch, U ;

Risau, W ;

Klein, R .

GENES & DEVELOPMENT, 1999, 13 (03) :295-306

[3] Serum vascular endothelial growth factor and Doppler blood flow velocities in in vitro fertilization: relevance to ovarian hyperstimulation syndrome and polycystic ovaries [J].

Agrawal, R ;

Conway, G ;

Sladkevicius, P ;

Tan, SL ;

Engmann, L ;

Payne, N ;

Bekir, J ;

Gampbell, S ;

Jacobs, H .

FERTILITY AND STERILITY, 1998, 70 (04) :651-658

[4] SUPPRESSION OF RETINAL NEOVASCULARIZATION IN-VIVO BY INHIBITION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) USING SOLUBLE VEGF-RECEPTOR CHIMERIC PROTEINS [J].

AIELLO, LP ;

PIERCE, EA ;

FOLEY, ED ;

TAKAGI, H ;

CHEN, H ;

RIDDLE, L ;

FERRARA, N ;

KING, GL ;

SMITH, LEH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10457-10461

[5] VASCULAR ENDOTHELIAL GROWTH-FACTOR IN OCULAR FLUID OF PATIENTS WITH DIABETIC-RETINOPATHY AND OTHER RETINAL DISORDERS [J].

AIELLO, LP ;

AVERY, RL ;

ARRIGG, PG ;

KEYT, BA ;

JAMPEL, HD ;

SHAH, ST ;

PASQUALE, LR ;

THIEME, H ;

IWAMOTO, MA ;

PARK, JE ;

NGUYEN, HV ;

AIELLO, LM ;

FERRARA, N ;

KING, GL .

NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (22) :1480-1487

[6] VASCULAR ENDOTHELIAL GROWTH-FACTOR ACTS AS A SURVIVAL FACTOR FOR NEWLY FORMED RETINAL-VESSELS AND HAS IMPLICATIONS FOR RETINOPATHY OF PREMATURITY [J].

ALON, T ;

HEMO, I ;

ITIN, A ;

PEER, J ;

STONE, J ;

KESHET, E .

NATURE MEDICINE, 1995, 1 (10) :1024-1028

[7]

[Anonymous], P AM SOC CLIN ONCOLO

[8] Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1 [J].

Barleon, B ;

Sozzani, S ;

Zhou, D ;

Weich, HA ;

Mantovani, A ;

Marme, D .

BLOOD, 1996, 87 (08) :3336-3343

[9] The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle [J].

Basset, DL .

AMERICAN JOURNAL OF ANATOMY, 1943, 73 (02) :251-291

[10] Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia [J].

Bellomo, D ;

Headrick, JP ;

Silins, GU ;

Paterson, CA ;

Thomas, PS ;

Gartside, M ;

Mould, A ;

Cahill, MM ;

Tonks, ID ;

Grimmond, SM ;

Townson, S ;

Wells, C ;

Little, M ;

Cummings, MC ;

Hayward, NK ;

Kay, GF .

CIRCULATION RESEARCH, 2000, 86 (02) :E29-E35

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