Lyophilization as a Method for Stabilizing Pharmaceuticals

被引：6

作者：

Nikolaeva, L. L. ^{[1
]}

Gulyakin, I. D. ^{[1
]}

Orlova, O. L. ^{[1
]}

Polozkova, A. P. ^{[1
]}

Oborotova, N. A. ^{[1
,2
]}

Sanarova, E. V. ^{[1
]}

Lantsova, A. V. ^{[1
]}

Khlamov, V. V. ^{[1
]}

Bunyatyan, N. D. ^{[2
]}

机构：

[1] Russian Acad Med Sci, NN Blokhin Russian Oncol Res Ctr, 24 Kashirskoe Shosse, Moscow 115478, Russia

[2] Sechenov First Moscow State Med Univ, Moscow 119991, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 04期

关键词：

freeze drying; excipients; lyophilizate structure; drying regime; liposomes; FORMULATION;

D O I：

10.1007/s11094-017-1604-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lyophilization (freeze drying) is among the most effective methods used to stabilize drugs and increase their shelf life. It is influenced by many factors, the most important of which are the properties of the parent drug substance and the excipients and the freezing and drying conditions. This review considers in detail the excipients used in lyophilized dosage forms and gives examples of sublimation regimes used for the lyophilization of some antitumor drugs.

引用

页码：307 / 311

页数：5

共 55 条

[21]

Gulyakin I. D., 2014, ROS BIOTER ZH, V1, P78

[22] A proposed rationale and test methodology for establishment of acceptance criteria for vacuum integrity testing of pharmaceutical freeze dryers [J].

Hardwick, Lisa M. ;

Nail, Steven L. ;

Jarman, James ;

Hasler, Kai ;

Hense, Thomas .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2013, 85 (02) :236-239

[23]

Ignateva E. V., 2013, ROSS BIOTERAPEVTICHE, V12, P36

[24]

Khugaeva O. V., 2010, ROSS BIOTERAPEVTICHE, V3, P51

[25]

Khugaeva O. V., 2012, ROSS BIOTERAPEVTICHE, V4, P41

[26]

Klochkova T. I., 2005, THESIS

[27]

Klochkova T. I., 2006, ROSS BIOTERAPEVTICHE, V3, P115

[28]

Kotova E. A., 2011, ROSS BIOTERAPEVTICHE, V10, P101

[29]

Kozeev S. G., 2012, ROS BIOTER ZH, V2, P24

[30]

Kulbachevskaya N. Yu., 2014, ROSS BIOTERAPEVTICHE, V1, P103

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