Pharmacoresistance - Epidemiology, mechanisms, and impact on epilepsy treatment

被引：85
作者：
Janmohamed, Mubeen [1 ]
Brodie, Martin J. [2 ]
Kwan, Patrick [1 ,3 ]
机构：
[1] Monash Univ, Alfred Hosp, Cent Clin Sch, Dept Neurosci, Melbourne, Vic, Australia
[2] Univ Glasgow, Glasgow, Lanark, Scotland
[3] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Neurol, Parkville, Vic, Australia
来源：
NEUROPHARMACOLOGY | 2020年 / 168卷
关键词：
Epilepsy; Pharmacoresistance; Epidemiology; Mechanisms; Risk factors; Treatment; VAGUS NERVE-STIMULATION; DRUG-RESISTANT EPILEPSY; TEMPORAL-LOBE EPILEPSY; RECEPTOR SUBUNIT EXPRESSION; ANTIEPILEPTIC DRUG; MULTIDRUG-RESISTANCE; UNCONTROLLED EPILEPSY; CONTROLLED-TRIAL; SEIZURE FREEDOM; ONSET SEIZURES;
D O I：
10.1016/j.neuropharm.2019.107790
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Understanding the natural history of and factors associated with pharmacoresistant epilepsy provides the foundation for formulating mechanistic hypotheses that can be evaluated to drive the development of novel treatments. This article reviews the modern definition of drug-resistant epilepsy, its prevalence and incidence, risk factors, hypothesized mechanisms, and the implication of recognizing pharmacoresistance in therapeutic strategies. This article is part of the special issue entitled 'New Epilepsy Therapies for the 21st Century - From Antiseizure Drugs to Prevention, Modification and Cure of Epilepsy'.
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页数：9
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