Role of medial hypothalamic orexin system in panic, phobia and hypertension

被引：12
作者：
Abreu, Aline R. [1 ]
Molosh, Andrei, I [1 ,2 ]
Johnson, Philip L. [2 ,3 ]
Shekhar, Anantha [1 ,2 ,3 ,4 ]
机构：
[1] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA
[2] Indiana Univ Sch Med, Paul & Carole Stark Neurosci Res Inst, Indianapolis, IN 46202 USA
[3] Indiana Univ Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA
[4] Indiana Univ Sch Med, Indiana Clin & Translat Sci Inst, Indianapolis, IN 46202 USA
来源：
BRAIN RESEARCH | 2020年 / 1731卷
关键词：
Orexin system; Hypertension; Anxiety; Panic; Fear; Sympathetic system; ROSTRAL VENTROLATERAL MEDULLA; STRESS-INDUCED TACHYCARDIA; GAMMA-AMINOBUTYRIC-ACID; SHORT-SLEEP DURATION; DORSOMEDIAL HYPOTHALAMUS; POSTERIOR HYPOTHALAMUS; ARTERIAL-PRESSURE; ELECTRICAL-STIMULATION; SYNAPTIC-TRANSMISSION; RECEPTOR ANTAGONISM;
D O I：
10.1016/j.brainres.2018.09.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Orexin has been implicated in a number of physiological functions, including arousal, regulation of sleep, energy metabolism, appetitive behaviors, stress, anxiety, fear, panic, and cardiovascular control. In this review, we will highlight research focused on orexin system in the medial hypothalamic regions of perifornical (PeF) and dorsomedial hypothalamus (DMH), and describe the role of this hypothalamic neuropeptide in the behavioral expression of panic and consequent fear and avoidance responses, as well as sympathetic regulation and possible development of chronic hypertension. We will also outline recent data highlighting the clinical potential of single and dual orexin receptor antagonists for neuropsychiatric conditions including panic, phobia, and cardiovascular conditions, such as in hypertension.
引用
收藏
页数：8
相关论文
共 146 条
  • [1] Distinct recognition of OX1 and OX2 receptors by orexin peptides
    Ammoun, S
    Holmqvist, T
    Shariatmadari, R
    Oonk, HB
    Detheux, M
    Parmentier, M
    Åkerman, KEO
    Kukkonen, JP
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 305 (02) : 507 - 514
  • [2] ANDERSON JJ, 1990, J PHARMACOL EXP THER, V255, P1399
  • [3] Panic disorder is associated with the Val308Iso polymorphism in the hypocretin receptor gene
    Annerbrink, Kristina
    Westberg, Lars
    Olsson, Marie
    Andersch, Sven
    Sjodin, Ingemar
    Holm, Goran
    Allgulander, Christer
    Eriksson, Elias
    [J]. PSYCHIATRIC GENETICS, 2011, 21 (02) : 85 - 89
  • [4] [Anonymous], [No title captured]
  • [5] [Anonymous], [No title captured]
  • [6] [Anonymous], [No title captured]
  • [7] [Anonymous], [No title captured]
  • [8] [Anonymous], [No title captured]
  • [9] [Anonymous], [No title captured]
  • [10] [Anonymous], [No title captured]
12345678910