Macrophage polarization in atherosclerosis

被引：170

作者：

Yang, Sai ^{[1
]}

Yuan, Hou-Qin ^{[1
]}

Hao, Ya-Meng ^{[1
]}

Ren, Zhong ^{[1
]}

Qu, Shun-Lin ^{[1
]}

Liu, Lu-Shan ^{[1
]}

Wei, Dang-Heng ^{[1
]}

Tang, Zhi-Han ^{[1
]}

Zhang, Ji-Feng ^{[2
]}

Jiang, Zhi-Sheng ^{[1
]}

机构：

[1] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerosis Hunan Prov, Hengyang City 421001, Hunan, Peoples R China

[2] Univ Michigan, Frankel Cardiovasc Ctr, Dept Internal Med, 2800 Plymouth Rd NCRC Bldg26-3575, Ann Arbor, MI 48109 USA

来源：

CLINICA CHIMICA ACTA | 2020年 / 501卷

基金：

中国国家自然科学基金;

关键词：

Atherosclerosis; Macrophage polarization; Phenotype; CARBON-MONOXIDE; INHIBITION; PHENOTYPE; MONOCYTES; PROMOTES;

D O I：

10.1016/j.cca.2019.10.034

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Atherosclerosis is a chronic inflammatory response that increases the risk of cardiovascular diseases. An in-depth study of the pathogenesis of atherosclerosis is critical for the treatment of atherosclerotic cardiovascular disease. The development of atherosclerosis involves many cells, such as endothelial cells, vascular smooth muscle cells, macrophages, and others. The considerable effects of macrophages in atherosclerosis are inextricably linked to macrophage polarization and the resulting phenotype. Moreover, the significant impact of macrophages on atherosclerosis depend not only on the function of the different macrophage phenotypes but also on the relative ratio of different phenotypes in the plaque. Research on atherosclerosis therapy indicates that the reduced plaque size and enhanced stability are partly due to modulating macrophage polarization. Therefore, regulating macrophage polarization and changing the proportion of macrophage phenotypes in plaques is a new therapeutic approach for atherosclerosis. This review provides a new perspective for atherosclerosis therapy by summarizing the relationship between macrophage polarization and atherosclerosis, as well as treatment targeting macrophage polarization.

引用

收藏

页码：142 / 146

页数：5

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