Impact of Arterial Hypertension and Use of Antihypertensive Pharmacotherapy on Mortality in Patients Hospitalized due to COVID-19: The CRACoV-HHS Study

被引：9

作者：

Wojciechowska, Wiktoria ^{[1
]}

Terlecki, Michal ^{[1
]}

Klocek, Marek ^{[1
]}

Pac, Agnieszka ^{[2
]}

Olszanecka, Agnieszka ^{[1
]}

Stolarz-Skrzypek, Katarzyna ^{[1
]}

Jastrzebski, Marek ^{[1
]}

Jankowski, Piotr ^{[1
]}

Ostrowska, Aleksandra ^{[1
]}

Drozdz, Tomasz ^{[1
]}

Prejbisz, Aleksander ^{[6
]}

Dobrowolski, Piotr ^{[6
]}

Januszewicz, Andrzej ^{[6
]}

Krzanowski, Marcin ^{[3
]}

Malecki, Maciej T. ^{[4
]}

Grodzicki, Tomasz ^{[5
]}

Kreutz, Reinhold ^{[7
,8
,9
,10
]}

Rajzer, Marek ^{[1
]}

机构：

[1] Jagiellonian Univ Med Coll, Dept Cardiol Intervent Electrocardiol & Arterial, Jakubowskiego St 2, PL-30688 Krakow, Poland

[2] Jagiellonian Univ Med Coll, Dept Epidemiol, Krakow, Poland

[3] Jagiellonian Univ Med Coll, Dept Rheumatol & Immunol, Krakow, Poland

[4] Jagiellonian Univ Med Coll, Dept Metab Dis & Diabetol, Krakow, Poland

[5] Jagiellonian Univ Med Coll, Dept Internal Med & Gerontol, Krakow, Poland

[6] Natl Inst Cardiol, Dept Hypertens, Warsaw, Poland

[7] Charite Univ Med Berlin, Berlin, Germany

[8] Free Univ Berlin, Berlin, Germany

[9] Humboldt Univ, Berlin, Germany

[10] Berlin Inst Hlth, Inst Clin Pharmacol & Toxicol, Berlin, Germany

来源：

HYPERTENSION | 2022年 / 79卷 / 11期

关键词：

blood pressure; COVID-19; hypertension; pandemic; mortality; risk factors; SARS-COV-2 INFECTION RECOMMENDATIONS; CORONAVIRUS DISEASE 2019; POLISH ASSOCIATION; BLOOD-PRESSURE; DISCONTINUATION; EPIDEMIOLOGISTS; MANAGEMENT; INHIBITORS;

D O I：

10.1161/HYPERTENSIONAHA.122.19575

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Background: Cardiovascular diseases including arterial hypertension are common comorbidities among patients hospitalized due to COVID-19. We assessed the influence of preexisting hypertension and its pharmacological treatment on in-hospital mortality in patients hospitalized with COVID-19. Methods: We studied all consecutive patients who were admitted to the University Hospital in Krakow, Poland, due to COVID-19 between March 2020 and May 2021. Data of 5191 patients (mean age 61.9 +/- 16.7 years, 45.2% female) were analyzed. Results: The median hospitalization time was 14 days, and the mortality rate was 18.4%. About a quarter of patients had an established cardiovascular disease including coronary artery disease (16.6%) or stroke (7.6%). Patients with hypertension (58.3%) were older and had more comorbidities than patients without hypertension. In multivariable logistic regression analysis, age above median (64 years), male gender, history of heart failure or chronic kidney disease, and higher C-reactive protein level, but not preexisting hypertension, were independent risk factors for in-hospital death in the whole study group. Patients with hypertension already treated (n=1723) with any first-line antihypertensive drug (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, calcium channel blockers, or thiazide/thiazide-like diuretics) had a significantly lower risk of in-hospital death (odds ratio, 0.25 [95% CI, 0.2-0.3]; P<0.001) compared to nontreated hypertensives (n=1305). Conclusions: Although the diagnosis of preexisting hypertension per se had no significant impact on in-hospital mortality among patients with COVID-19, treatment with any first-line blood pressure-lowering drug had a profound beneficial effect on survival in patients with hypertension. These data support the need for antihypertensive pharmacological treatment during the COVID-19 pandemic.

引用

页码：2601 / 2610

页数：10

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