Optimization of the trace element determination by ICP-MS in human blood serum

被引：46
|
作者：
Bravo, Isabel De Blas [1 ]
Castro, Ramon Sanz [1 ]
Riquelme, Natividad Lopez [2 ]
Diaz, Consuelo Tormo [2 ]
Goyenaga, David Apraiz [1 ]
机构：
[1] Applus LABAQUA Alicante, Pologono Ind Las Atalayas, Alicante 03114, Spain
[2] Gen & Univ Hosp, Clin Lab Dept, Elche 03203, Spain
来源：
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2007年 / 21卷
关键词：
ICP-MS; human blood serum; trace element; pre-treatment; optimization;
D O I：
10.1016/j.jtemb.2007.09.017
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ICP-MS for simultaneous trace element determination in human blood has prevailed as the most suitable methodology for clinical aims because of its rapidity, detection limits and minimal sample quantity needed for analysis. As the proteic matrix is high, it is necessary to fine-tune the ICP-MS Agilent 75001 with autosampler CETAC ASX-500 and ISIS System connected, and further we have to the sample pre-treatment in order to obtain good results. The study of the results shows that the best pre-treatment for blood serum samples consists of a basic treatment by 1/10 dilution with a solution of EDTA and NH4OH, with a detection limit of the order of mu g/L and a reduction of the necessary patient sample volume to 2 mL. (c) 2007 Elsevier GmbH. All rights reserved.
引用
收藏
页码：14 / 17
页数：4
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